GJB3 (gap junction protein beta 3)

2014-11-01  

Identity

HGNC
LOCATION
1p34.3
LOCUSID
ALIAS
CX31,DFNA2,DFNA2B,EKV,EKVP1

Other Information

Locus ID:

NCBI: 2707
MIM: 603324
HGNC: 4285
Ensembl: ENSG00000188910

Variants:

dbSNP: 2707
ClinVar: 2707
TCGA: ENSG00000188910
COSMIC: GJB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000188910ENST00000373362O75712
ENSG00000188910ENST00000373366O75712

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction assemblyREACTOMER-HSA-190861

References

Pubmed IDYearTitleCitations
380295952024Mutation analysis of GJB2, SLC26A4, GJB3 and mtDNA12SrRNA genes in 251 non-syndromic hearing loss patients in Fujian, China.0
389564972024Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion.0
380295952024Mutation analysis of GJB2, SLC26A4, GJB3 and mtDNA12SrRNA genes in 251 non-syndromic hearing loss patients in Fujian, China.0
389564972024Impairment of α-tubulin and F-actin interactions of GJB3 induces aneuploidy in urothelial cells and promotes bladder cancer cell invasion.0
315990152020Case of erythrokeratodermia variabilis successfully treated with narrowband ultraviolet B.1
326456182020The mutation frequencies of GJB2, GJB3, SLC26A4 and MT-RNR1 of patients with severe to profound sensorineural hearing loss in northwest China.9
315990152020Case of erythrokeratodermia variabilis successfully treated with narrowband ultraviolet B.1
326456182020The mutation frequencies of GJB2, GJB3, SLC26A4 and MT-RNR1 of patients with severe to profound sensorineural hearing loss in northwest China.9
295702242019A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death.8
299925522019Exome sequencing identifies novel compound heterozygous mutations in GJB3 gene that cause erythrokeratodermia variabilis et progressiva.2
310351782019Mutation analysis of common deafness-causing genes among 506 patients with nonsyndromic hearing loss from Wenzhou city, China.11
295702242019A rare missense mutation in GJB3 (Cx31G45E) is associated with a unique cellular phenotype resulting in necrotic cell death.8
299925522019Exome sequencing identifies novel compound heterozygous mutations in GJB3 gene that cause erythrokeratodermia variabilis et progressiva.2
310351782019Mutation analysis of common deafness-causing genes among 506 patients with nonsyndromic hearing loss from Wenzhou city, China.11
299269812018GJB3/GJB6 screening in GJB2 carriers with idiopathic hearing loss: Is it necessary?5

Citation

Dessen P

GJB3 (gap junction protein beta 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63798/gjb3-(gap-junction-protein-beta-3)