GJD2 (gap junction protein delta 2)

2014-11-01  

Identity

HGNC
LOCATION
15q14
LOCUSID
ALIAS
CX36,GJA9

Other Information

Locus ID:

NCBI: 57369
MIM: 607058
HGNC: 19154
Ensembl: ENSG00000159248

Variants:

dbSNP: 57369
ClinVar: 57369
TCGA: ENSG00000159248
COSMIC: GJD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000159248ENST00000290374Q9UKL4

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Gap junctionKEGGko04540
Gap junctionKEGGhsa04540
Neuronal SystemREACTOMER-HSA-112316
Transmission across Electrical SynapsesREACTOMER-HSA-112307
Electric Transmission Across Gap JunctionsREACTOMER-HSA-112303
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
Gap junction trafficking and regulationREACTOMER-HSA-157858
Gap junction traffickingREACTOMER-HSA-190828
Gap junction assemblyREACTOMER-HSA-190861

References

Pubmed IDYearTitleCitations
384903112024Assembly mechanisms of the neuronal gap junction channel connexin 36 elucidated by Cryo-EM.0
384903112024Assembly mechanisms of the neuronal gap junction channel connexin 36 elucidated by Cryo-EM.0
369066532023Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.7
375788902023Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction.3
369066532023Cryo-EM structures of human Cx36/GJD2 neuronal gap junction channel.7
375788902023Restoring connexin-36 function in diabetogenic environments precludes mouse and human islet dysfunction.3
352627312022The Role of GJD2(Cx36) in Refractive Error Development.3
358859492022Association of CX36 Protein Encoding Gene GJD2 with Refractive Errors.1
352627312022The Role of GJD2(Cx36) in Refractive Error Development.3
358859492022Association of CX36 Protein Encoding Gene GJD2 with Refractive Errors.1
344063322021Phenotypic Consequences of the GJD2 Risk Genotype in Myopia Development.4
344063322021Phenotypic Consequences of the GJD2 Risk Genotype in Myopia Development.4
292467912018A potential role for neuronal connexin 36 in the pathogenesis of amyotrophic lateral sclerosis.8
292988772018Molecular basis for potentiation of Cx36 gap junction channel conductance by n-alcohols and general anesthetics.4
297934452018Heritability of myopia and its relation with GDJ2 and RASGRF1 genes in Lithuania.8

Citation

Dessen P

GJD2 (gap junction protein delta 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63801/gjd2-(gap-junction-protein-delta-2)