GLCCI1 (glucocorticoid induced 1)

2014-11-01  

Identity

HGNC
GLCCI1
LOCATION
7p21.3
LOCUSID
113263
ALIAS
FAM117C,GCTR,GIG18,TSSN1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 113263
MIM: 614283
HGNC: 18713
Ensembl: ENSG00000106415

Variants:

dbSNP: 113263
ClinVar: 113263
TCGA: ENSG00000106415
COSMIC: GLCCI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000106415ENST00000223145Q86VQ1
ENSG00000106415ENST00000414914H7C2L5
ENSG00000106415ENST00000430798H7C0Q2
ENSG00000106415ENST00000438949H7C0B2

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10832corticosteroidsChemicalVariantAnnotationnot associatedPD27523435
PA443450AsthmaDiseaseClinicalAnnotation, VariantAnnotationambiguousPD21991891, 27523435
PA448681budesonideChemicalClinicalAnnotationassociatedPD21991891
PA449661flunisolideChemicalClinicalAnnotationassociatedPD21991891
PA449686fluticasone propionateChemicalClinicalAnnotationassociatedPD21991891
PA450601nedocromilChemicalClinicalAnnotationassociatedPD21991891
PA451749triamcinoloneChemicalClinicalAnnotationassociatedPD21991891
PA452347glucocorticoidsChemicalClinicalAnnotationassociatedPD21991891

References

Pubmed IDYearTitleCitations
375539502023Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population.0
375539502023Glucocorticoid-Induced Transcript 1(GLCCI1) SNP rs37937 Is Associated With the Risk of Developing Allergic Rhinitis and the Response to Intranasal Corticosteroids in a Chinese Han Population.0
315160812021GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.5
337255702021Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.8
345299842021GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.1
315160812021GLCCI1 and STIP1 variants are associated with asthma susceptibility and inhaled corticosteroid response in a Tunisian population.5
337255702021Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.8
345299842021GLCCI1 gene body methylation in peripheral blood is associated with asthma and asthma severity.1
332081312020Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.4
332081312020Effects of STIP1 and GLCCI1 polymorphisms on the risk of childhood asthma and inhaled corticosteroid response in Chinese asthmatic children.4
302293112019A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.2
308608712019GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.9
302293112019A single-nucleotide polymorphism in a gene modulating glucocorticoid sensitivity is associated with the decline in total lung capacity after lung transplantation.2
308608712019GLCCI1 is a novel protector against glucocorticoid-induced apoptosis in T cells.9
284883222018Impact of the genetic variants of GLCCI1 on clinical features of asthmatic patients.4

Citation

Dessen P

GLCCI1 (glucocorticoid induced 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63813/glcci1-(glucocorticoid-induced-1)