GMIP (GEM interacting protein)

2014-11-01  

Identity

HGNC
GMIP
LOCATION
19p13.11
LOCUSID
51291
ALIAS
ARHGAP46
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51291
MIM: 609694
HGNC: 24852
Ensembl: ENSG00000089639

Variants:

dbSNP: 51291
ClinVar: 51291
TCGA: ENSG00000089639
COSMIC: GMIP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000089639ENST00000203556Q9P107
ENSG00000089639ENST00000203556A0A024R7N1
ENSG00000089639ENST00000587205K7EQR5
ENSG00000089639ENST00000587238Q9P107
ENSG00000089639ENST00000588171K7ELE8
ENSG00000089639ENST00000591047K7ELE8
ENSG00000089639ENST00000593186K7EJC2

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
251738852014Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.5
251738852014Gem GTPase acts upstream Gmip/RhoA to regulate cortical actin remodeling and spindle positioning during early mitosis.5
224385812012Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.48
224385812012Vesicular trafficking through cortical actin during exocytosis is regulated by the Rab27a effector JFC1/Slp1 and the RhoA-GTPase-activating protein Gem-interacting protein.48
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.119
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.119
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.15
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.105
160861842005The Gem interacting protein (GMIP) gene is associated with major depressive disorder.7
160861842005The Gem interacting protein (GMIP) gene is associated with major depressive disorder.7
160861842005The Gem interacting protein (GMIP) gene is associated with major depressive disorder.7
160861842005The Gem interacting protein (GMIP) gene is associated with major depressive disorder.7
120933602002A novel Rho GTPase-activating-protein interacts with Gem, a member of the Ras superfamily of GTPases.24

Citation

Dessen P

GMIP (GEM interacting protein)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63854/gmip-(gem-interacting-protein)