GPHA2 (glycoprotein hormone subunit alpha 2)

2014-11-01  

Identity

HGNC
LOCATION
11q13.1
LOCUSID
ALIAS
A2,GPA2,ZSIG51

Other Information

Locus ID:

NCBI: 170589
MIM: 609651
HGNC: 18054
Ensembl: ENSG00000149735

Variants:

dbSNP: 170589
ClinVar: 170589
TCGA: ENSG00000149735
COSMIC: GPHA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000149735ENST00000279168Q96T91
ENSG00000149735ENST00000279168A0A024R579
ENSG00000149735ENST00000532246E9PLQ0
ENSG00000149735ENST00000533257Q96T91
ENSG00000149735ENST00000533257A0A024R579

Expression (GTEx)

0
5
10
15
20
25
30

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Hormone ligand-binding receptorsREACTOMER-HSA-375281
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

References

Pubmed IDYearTitleCitations
382465722024Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling.0
382465722024Glycoprotein hormone subunit alpha 2 (GPHA2): A pituitary stem cell-expressed gene associated with NOTCH2 signaling.0
260182492015Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.20
260182492015Thyrostimulin Regulates Osteoblastic Bone Formation During Early Skeletal Development.20
184338982008Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5).12
184338982008Biochemical roles of the oligosaccharide chains in thyrostimulin, a heterodimeric hormone of glycoprotein hormone subunits alpha 2 (GPA2) and beta 5 (GPB5).12
173630772007The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin.0
173630772007The LIM domain homeobox gene isl-1 is a positive regulator of glycoprotein alpha 2 (GPA2), a subunit of thyrostimulin.0
158907692005Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.37
163764812005Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit.1
158907692005Heterodimeric fly glycoprotein hormone-alpha2 (GPA2) and glycoprotein hormone-beta5 (GPB5) activate fly leucine-rich repeat-containing G protein-coupled receptor-1 (DLGR1) and stimulation of human thyrotropin receptors by chimeric fly GPA2 and human GPB5.37
163764812005Promoter cloning and characterisation of the transcriptional regulation of the human thyrostimulin A2 subunit.1
120893492002Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.38
120893492002Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5.38

Citation

Dessen P

GPHA2 (glycoprotein hormone subunit alpha 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63935/gpha2-(glycoprotein-hormone-subunit-alpha-2)