GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)

2014-11-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
GPI-HBP1,HYPL1D

Other Information

Locus ID:

NCBI: 338328
MIM: 612757
HGNC: 24945
Ensembl: ENSG00000277494

Variants:

dbSNP: 338328
ClinVar: 338328
TCGA: ENSG00000277494
COSMIC: GPIHBP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000277494ENST00000622500Q8IV16

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Post-translational modification: synthesis of GPI-anchored proteinsREACTOMER-HSA-163125
Signal TransductionREACTOMER-HSA-162582
Visual phototransductionREACTOMER-HSA-2187338
Retinoid metabolism and transportREACTOMER-HSA-975634
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Lipid digestion, mobilization, and transportREACTOMER-HSA-73923
Lipoprotein metabolismREACTOMER-HSA-174824
Chylomicron-mediated lipid transportREACTOMER-HSA-174800
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of fat-soluble vitaminsREACTOMER-HSA-6806667

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
386225732024Familial chylomicronemia syndrome: case reports of siblings with deletions of the GPIHBP1 gene.0
386225732024Familial chylomicronemia syndrome: case reports of siblings with deletions of the GPIHBP1 gene.0
378712172023The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.2
378712172023The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing.2
351013602022Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study.2
360373402022A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism.6
351013602022Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study.2
360373402022A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism.6
337060812021A novel GPIHBP1 mutation related to familial chylomicronemia syndrome: A series of cases.11
337060812021A novel GPIHBP1 mutation related to familial chylomicronemia syndrome: A series of cases.11
316454342020A lipoprotein lipase-GPI-anchored high-density lipoprotein-binding protein 1 fusion lowers triglycerides in mice: Implications for managing familial chylomicronemia syndrome.11
323324312020Regulation of lipoprotein lipase-mediated lipolysis of triglycerides.36
327714832020The antagonic behavior of GPIHBP1 between EAT and circulation does not reflect lipolytic enzymes levels in the tissue and serum from coronary patients.1
328580552020Changes in serum levels of angiopoietin-like protein-8 and glycosylphosphatidylinositol-anchored high-density lipoprotein binding protein 1 after ezetimibe therapy in patients with dyslipidemia.2
329486622020Chylomicronemia from GPIHBP1 autoantibodies.12

Citation

Dessen P

GPIHBP1 (glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63937/gpihbp1-(glycosylphosphatidylinositol-anchored-high-density-lipoprotein-binding-protein-1)