GPR176 (G protein-coupled receptor 176)

2014-11-01  

Identity

HGNC
GPR176
LOCATION
15q14
LOCUSID
11245
ALIAS
HB-954
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11245
MIM: 612183
HGNC: 32370
Ensembl: ENSG00000166073

Variants:

dbSNP: 11245
ClinVar: 11245
TCGA: ENSG00000166073
COSMIC: GPR176

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166073ENST00000299092Q14439
ENSG00000166073ENST00000543580Q14439
ENSG00000166073ENST00000561100Q14439

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
388352342024The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy.0
388352342024The oncogenic roles of GPR176 in ovarian cancer: a molecular target for aggressiveness and gene therapy.0
369052382023GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.8
372911812023High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.0
375847122023The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.0
369052382023GPR176 Promotes Cancer Progression by Interacting with G Protein GNAS to Restrain Cell Mitophagy in Colorectal Cancer.8
372911812023High expression of GPR176 predicts poor prognosis of gastric cancer patients and promotes the proliferation, migration, and invasion of gastric cancer cells.0
375847122023The promoting effects of GPR176 expression on proliferation, chemoresistance, lipogenesis and invasion of oesophageal cancer.0
285029232017G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].8
285029232017G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].8
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.19

Citation

Dessen P

GPR176 (G protein-coupled receptor 176)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63979/gpr176-(g-protein-coupled-receptor-176)