GPR3 (G protein-coupled receptor 3)

2014-11-01  

Identity

HGNC
GPR3
LOCATION
1p36.11
LOCUSID
2827
ALIAS
ACCA

Other Information

Locus ID:

NCBI: 2827
MIM: 600241
HGNC: 4484
Ensembl: ENSG00000181773

Variants:

dbSNP: 2827
ClinVar: 2827
TCGA: ENSG00000181773
COSMIC: GPR3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000181773ENST00000374024P46089
ENSG00000181773ENST00000374024F1DAM5

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
379198102023Rare variants in GPR3 in POI patients: a case series with review of literature.0
379198102023Rare variants in GPR3 in POI patients: a case series with review of literature.0
340487002021Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.42
343020562021Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.2
340487002021Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis.42
343020562021Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation.2
315160762020Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.2
315160762020Development of a High-Throughput Screening-Compatible Assay for Discovery of GPR3 Inverse Agonists Using a cAMP Biosensor.2
300383192018Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.12
300383192018Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production.12
237326632013[G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].0
238260792013Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.10
240693302013Gpr3 stimulates Aβ production via interactions with APP and β-arrestin2.21
237326632013[G protein-coupled receptor 3: a key factor in the regulation of the nervous system and follicle development].0
238260792013Regulation of Constitutive GPR3 Signaling and Surface Localization by GRK2 and β-arrestin-2 Overexpression in HEK293 Cells.10

Citation

Dessen P

GPR3 (G protein-coupled receptor 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/63989/gpr3-(g-protein-coupled-receptor-3)