Identity
HGNC
LOCATION
5q11.2
LOCUSID
ALIAS
EPLA847,GPx-8,GSHPx-8,UNQ847
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 493869
MIM: 617172
HGNC: 33100
Ensembl: ENSG00000164294
Variants:
dbSNP: 493869
ClinVar: 493869
TCGA: ENSG00000164294
COSMIC: GPX8
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000164294 | ENST00000296734 | J3KNB5 |
| ENSG00000164294 | ENST00000503787 | Q8TED1 |
| ENSG00000164294 | ENST00000515370 | E7ETY7 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38515109 | 2024 | GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. | 2 |
| 38515109 | 2024 | GPX8(+) cancer-associated fibroblast, as a cancer-promoting factor in lung adenocarcinoma, is related to the immunosuppressive microenvironment. | 2 |
| 37170591 | 2023 | GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. | 4 |
| 37795080 | 2023 | GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. | 1 |
| 37170591 | 2023 | GPX8 deficiency-induced oxidative stress reprogrammed m6A epitranscriptome of oral cancer cells. | 4 |
| 37795080 | 2023 | GPX8 regulates pan-apoptosis in gliomas to promote microglial migration and mediate immunotherapy responses. | 1 |
| 35288240 | 2022 | GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway. | 5 |
| 36052280 | 2022 | GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. | 3 |
| 35288240 | 2022 | GPx8 regulates apoptosis and autophagy in esophageal squamous cell carcinoma through the IRE1/JNK pathway. | 5 |
| 36052280 | 2022 | GPX8 as a Novel Prognostic Factor and Potential Therapeutic Target in Primary Glioma. | 3 |
| 32392186 | 2020 | Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data. | 8 |
| 32719007 | 2020 | Characterization of the endoplasmic reticulum-resident peroxidases GPx7 and GPx8 shows the higher oxidative activity of GPx7 and its linkage to oxidative protein folding. | 16 |
| 32817494 | 2020 | The glutathione peroxidase 8 (GPX8)/IL-6/STAT3 axis is essential in maintaining an aggressive breast cancer phenotype. | 29 |
| 32975378 | 2020 | GPX8 promotes migration and invasion by regulating epithelial characteristics in non-small cell lung cancer. | 13 |
| 32392186 | 2020 | Glutathione Peroxidase 8 as a Prognostic Biomarker of Gastric Cancer: An Analysis of The Cancer Genome Atlas (TCGA) Data. | 8 |
Citation
Dessen P
GPX8 (glutathione peroxidase 8 (putative))
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64024/gpx8-(glutathione-peroxidase-8-(putative))
