Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 64388
MIM: 608832
HGNC: 17655
Ensembl: ENSG00000180875
Variants:
dbSNP: 64388
ClinVar: 64388
TCGA: ENSG00000180875
COSMIC: GREM2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000180875 | ENST00000318160 | Q9H772 |
| ENSG00000180875 | ENST00000318160 | A0A024R3Y1 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Signal Transduction | REACTOME | R-HSA-162582 |
| Signaling by BMP | REACTOME | R-HSA-201451 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA448320 | allopurinol | Chemical | ClinicalAnnotation, VariantAnnotation | associated | PD | 30924126 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 35349825 | 2022 | GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning. | 3 |
| 35619575 | 2022 | MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression. | 4 |
| 35349825 | 2022 | GREM2 is associated with human central obesity and inhibits visceral preadipocyte browning. | 3 |
| 35619575 | 2022 | MiR-103a-3p Contributes to the Progression of Colorectal Cancer by Regulating GREM2 Expression. | 4 |
| 33369218 | 2021 | Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis. | 3 |
| 33369218 | 2021 | Functional characterization of ATF1, GREM2 AND WNT10B variants associated with tooth agenesis. | 3 |
| 32297643 | 2020 | Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women. | 3 |
| 33144675 | 2020 | Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway. | 48 |
| 32297643 | 2020 | Association of Gremlin-2 gene polymorphisms with osteoporosis risk in Chinese postmenopausal women. | 3 |
| 33144675 | 2020 | Cancer-associated fibroblast-secreted exosomal miR-423-5p promotes chemotherapy resistance in prostate cancer by targeting GREM2 through the TGF-β signaling pathway. | 48 |
| 30831151 | 2019 | Grem2 mediates podocyte apoptosis in high glucose milieu. | 9 |
| 30831151 | 2019 | Grem2 mediates podocyte apoptosis in high glucose milieu. | 9 |
| 28992378 | 2018 | GREM2 nucleotide variants and the risk of tooth agenesis. | 5 |
| 30014930 | 2018 | Association betweenGREM2 gene polymorphism with osteoporosis and osteopenia in postmenopausal women. | 5 |
| 30246922 | 2018 | Further evidence for the role of WNT10A, WNT10B and GREM2 as candidate genes for isolated tooth agenesis. | 9 |
Citation
Dessen P
GREM2 (gremlin 2, DAN family BMP antagonist)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64033/grem2-(gremlin-2-dan-family-bmp-antagonist)
