Identity
HGNC
LOCATION
21q21.3
LOCUSID
ALIAS
EAA3,EEA3,GLR5,GLUR5,GluK1,gluR-5
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2897
MIM: 138245
HGNC: 4579
Ensembl: ENSG00000171189
Variants:
dbSNP: 2897
ClinVar: 2897
TCGA: ENSG00000171189
COSMIC: GRIK1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA446879 | Alcohol-Related Disorders | Disease | ClinicalAnnotation | associated | PK | PD | 19331489 |
| PA451728 | topiramate | Chemical | ClinicalAnnotation | associated | PK | PD | 19331489 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36323684 | 2022 | Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands. | 2 |
| 36323684 | 2022 | Kainate receptor subunit 1 (GRIK1) risk variants and GRIK1 deficiency were detected in the Indian ADHD probands. | 2 |
| 34060082 | 2021 | In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes. | 2 |
| 34060082 | 2021 | In vivo hippocampal cornu ammonis 1-3 glutamatergic abnormalities are associated with temporal lobe epilepsy surgery outcomes. | 2 |
| 25496338 | 2016 | Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking. | 11 |
| 27447243 | 2016 | Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. | 4 |
| 25496338 | 2016 | Self-efficacy mediates the effects of topiramate and GRIK1 genotype on drinking. | 11 |
| 27447243 | 2016 | Association study of DRD2 A2/A1, DRD3 Ser9Gly, DβH -1021C>T, OPRM1 A118G and GRIK1 rs2832407C>A polymorphisms with alcohol dependence. | 4 |
| 25941919 | 2015 | Gene-gene interaction of μ-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect. | 0 |
| 26277340 | 2015 | The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors. | 9 |
| 26289945 | 2015 | The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. | 16 |
| 25941919 | 2015 | Gene-gene interaction of μ-opioid receptor and GluR5 kainate receptor subunit is associated with smoking behavior in a Greek population: presence of a dose allele effect. | 0 |
| 26277340 | 2015 | The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors. | 9 |
| 26289945 | 2015 | The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving. | 16 |
| 24525690 | 2014 | Topiramate treatment for heavy drinkers: moderation by a GRIK1 polymorphism. | 87 |
Citation
Dessen P
GRIK1 (glutamate ionotropic receptor kainate type subunit 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64039/grik1-(glutamate-ionotropic-receptor-kainate-type-subunit-1)
