Identity
HGNC
LOCATION
11q23.3
LOCUSID
ALIAS
EAA1,GRIK,GluK4,KA1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2900
MIM: 600282
HGNC: 4582
Ensembl: ENSG00000149403
Variants:
dbSNP: 2900
ClinVar: 2900
TCGA: ENSG00000149403
COSMIC: GRIK4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149403 | ENST00000438375 | Q16099 |
| ENSG00000149403 | ENST00000527524 | Q16099 |
| ENSG00000149403 | ENST00000638419 | Q16099 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447207 | Depressive Disorder | Disease | ClinicalAnnotation | associated | PD | 17671280, 19924111, 23394390 | |
| PA447278 | Depression | Disease | ClinicalAnnotation | associated | PD | 17671280, 23394390 | |
| PA447321 | Depressive Disorder, Major | Disease | ClinicalAnnotation | associated | PD | 17671280, 23394390 | |
| PA449841 | haloperidol | Chemical | MultilinkAnnotation | associated | 27023437 | ||
| PA452229 | antidepressants | Chemical | ClinicalAnnotation | associated | PD | 17671280, 19924111, 23394390 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32245654 | 2020 | Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression. | 0 |
| 32245654 | 2020 | Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression. | 0 |
| 29243543 | 2019 | A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort. | 2 |
| 31066578 | 2019 | Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders. | 17 |
| 29243543 | 2019 | A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort. | 2 |
| 31066578 | 2019 | Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders. | 17 |
| 28284346 | 2017 | AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women. | 14 |
| 28583584 | 2017 | Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population. | 3 |
| 28658089 | 2017 | No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population. | 2 |
| 28284346 | 2017 | AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women. | 14 |
| 28583584 | 2017 | Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population. | 3 |
| 28658089 | 2017 | No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population. | 2 |
| 26139080 | 2015 | The role of GRIK4 gene in treatment-resistant depression. | 7 |
| 26139080 | 2015 | The role of GRIK4 gene in treatment-resistant depression. | 7 |
| 25303296 | 2014 | GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis. | 9 |
Citation
Dessen P
GRIK4 (glutamate ionotropic receptor kainate type subunit 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64044/grik4-(glutamate-ionotropic-receptor-kainate-type-subunit-4)
