GRIK4 (glutamate ionotropic receptor kainate type subunit 4)

2014-11-01 Affiliation

Identity

HGNC

GRIK4

LOCATION

11q23.3

LOCUSID

2900

ALIAS

EAA1,GRIK,GluK4,KA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 2900
MIM: 600282
HGNC: 4582
Ensembl: ENSG00000149403

Variants:

dbSNP: 2900
ClinVar: 2900
TCGA: ENSG00000149403
COSMIC: GRIK4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000149403	ENST00000438375	Q16099
ENSG00000149403	ENST00000527524	Q16099
ENSG00000149403	ENST00000638419	Q16099

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuroactive ligand-receptor interaction	KEGG	ko04080
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Glutamatergic synapse	KEGG	ko04724
Glutamatergic synapse	KEGG	hsa04724
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Activation of Kainate Receptors upon glutamate binding	REACTOME	R-HSA-451326
Ionotropic activity of Kainate Receptors	REACTOME	R-HSA-451306
Activation of Ca-permeable Kainate Receptor	REACTOME	R-HSA-451308

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA447207	Depressive Disorder	Disease	ClinicalAnnotation	associated	PD	17671280, 19924111, 23394390
PA447278	Depression	Disease	ClinicalAnnotation	associated	PD	17671280, 23394390
PA447321	Depressive Disorder, Major	Disease	ClinicalAnnotation	associated	PD	17671280, 23394390
PA449841	haloperidol	Chemical	MultilinkAnnotation	associated		27023437
PA452229	antidepressants	Chemical	ClinicalAnnotation	associated	PD	17671280, 19924111, 23394390

References

Pubmed ID	Year	Title	Citations
32245654	2020	Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression.	0
32245654	2020	Impact of GRIK4 gene polymorphisms on cognitive dysfunction in patients with major depression.	0
29243543	2019	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort.	2
31066578	2019	Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.	17
29243543	2019	A kainate receptor GluK4 deletion, protective against bipolar disorder, is associated with enhanced cognitive performance across diagnoses in the TwinsUK cohort.	2
31066578	2019	Pharmacogenetics of Sertraline Tolerability and Response in Pediatric Anxiety and Depressive Disorders.	17
28284346	2017	AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.	14
28583584	2017	Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population.	3
28658089	2017	No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population.	2
28284346	2017	AMPA, NMDA and kainate glutamate receptor subunits are expressed in human peripheral blood mononuclear cells (PBMCs) where the expression of GluK4 is altered by pregnancy and GluN2D by depression in pregnant women.	14
28583584	2017	Common variants in GRIK4 and major depressive disorder: An association study in the Chinese Han population.	3
28658089	2017	No association of GRIK4 polymorphisms with schizophrenia in the Chinese Han population.	2
26139080	2015	The role of GRIK4 gene in treatment-resistant depression.	7
26139080	2015	The role of GRIK4 gene in treatment-resistant depression.	7
25303296	2014	GRIK4 polymorphism and its association with antidepressant response in depressed patients: a meta-analysis.	9

Citation

Dessen P

GRIK4 (glutamate ionotropic receptor kainate type subunit 4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64044/grik4-(glutamate-ionotropic-receptor-kainate-type-subunit-4)