GRM6 (glutamate metabotropic receptor 6)

2014-11-01  

Identity

HGNC
LOCATION
5q35.3
LOCUSID
ALIAS
CSNB1B,GPRC1F,MGLUR6,mGlu6

Other Information

Locus ID:

NCBI: 2916
MIM: 604096
HGNC: 4598
Ensembl: ENSG00000113262

Variants:

dbSNP: 2916
ClinVar: 2916
TCGA: ENSG00000113262
COSMIC: GRM6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000113262ENST00000231188O15303
ENSG00000113262ENST00000517717O15303
ENSG00000113262ENST00000650031O15303

Expression (GTEx)

0
1
2

Pathways

PathwaySourceExternal ID
Neuroactive ligand-receptor interactionKEGGko04080
Neuroactive ligand-receptor interactionKEGGhsa04080
Glutamatergic synapseKEGGko04724
Glutamatergic synapseKEGGhsa04724
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class C/3 (Metabotropic glutamate/pheromone receptors)REACTOMER-HSA-420499
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
310630162019Identification of a novel GRM6 mutation in a previously described consanguineous family with complete congenital stationary night blindness.1
316772492019Pseudodominant inheritance of autosomal recessive congenital stationary night blindness in one family with three co-segregating deleterious GRM6 variants identified by next-generation sequencing.6
310630162019Identification of a novel GRM6 mutation in a previously described consanguineous family with complete congenital stationary night blindness.1
316772492019Pseudodominant inheritance of autosomal recessive congenital stationary night blindness in one family with three co-segregating deleterious GRM6 variants identified by next-generation sequencing.6
270342042016Association of ZNF644, GRM6, and CTNND2 genes with high myopia in the Han Chinese population: Jiangsu Eye Study.14
270342042016Association of ZNF644, GRM6, and CTNND2 genes with high myopia in the Han Chinese population: Jiangsu Eye Study.14
266288572015Mutations in GRM6 identified in consanguineous Pakistani families with congenital stationary night blindness.5
266288572015Mutations in GRM6 identified in consanguineous Pakistani families with congenital stationary night blindness.5
234523482013Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.19
237143222013Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.53
234523482013Metabotropic glutamate receptor 6 signaling enhances TRPM1 calcium channel function and increases melanin content in human melanocytes.19
237143222013Genotype and phenotype of 101 dutch patients with congenital stationary night blindness.53
220082502012A phenotypic study of congenital stationary night blindness (CSNB) associated with mutations in the GRM6 gene.17
227357942012Mutation screening of TRPM1, GRM6, NYX and CACNA1F genes in patients with congenital stationary night blindness.5
229593592012Assessing retinal structure in complete congenital stationary night blindness and Oguchi disease.37

Citation

Dessen P

GRM6 (glutamate metabotropic receptor 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64052/grm6-(glutamate-metabotropic-receptor-6)