Identity
HGNC
LOCATION
3p26.1
LOCUSID
ALIAS
GLUR7,GPRC1G,MGLU7,MGLUR7,NEDSHBA,PPP1R87
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 2917
MIM: 604101
HGNC: 4599
Ensembl: ENSG00000196277
Variants:
dbSNP: 2917
ClinVar: 2917
TCGA: ENSG00000196277
COSMIC: GRM7
RNA/Proteins
Expression (GTEx)
Pathways
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA447197 | Attention Deficit Disorder with Hyperactivity | Disease | VariantAnnotation | not associated | PD | ||
| PA450464 | methylphenidate | Chemical | VariantAnnotation | not associated | PD | ||
| PA451257 | risperidone | Chemical | ClinicalAnnotation | associated | PD | 26905411 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38070825 | 2024 | GRM7-related disorder: five additional patients from three independent families and review of the literature. | 2 |
| 38070825 | 2024 | GRM7-related disorder: five additional patients from three independent families and review of the literature. | 2 |
| 36597080 | 2023 | Correlation between variants of the CREB1 and GRM7 genes and risk of depression. | 2 |
| 37003303 | 2023 | GRM7 gene mutations and consequences for neurodevelopment. | 2 |
| 37882887 | 2023 | Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy. | 0 |
| 36597080 | 2023 | Correlation between variants of the CREB1 and GRM7 genes and risk of depression. | 2 |
| 37003303 | 2023 | GRM7 gene mutations and consequences for neurodevelopment. | 2 |
| 37882887 | 2023 | Associations between GRM7 polymorphisms and obesity in patients selected for sleeve gastrectomy. | 0 |
| 32624350 | 2022 | A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis. | 6 |
| 32624350 | 2022 | A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis. | 6 |
| 33068816 | 2021 | Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci. | 6 |
| 33476302 | 2021 | A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. | 13 |
| 34135509 | 2021 | Structures of human mGlu2 and mGlu7 homo- and heterodimers. | 47 |
| 34273994 | 2021 | A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity. | 3 |
| 33068816 | 2021 | Association between the group III metabotropic glutamate receptor gene polymorphisms and attention-deficit/hyperactivity disorder and functional exploration of risk loci. | 6 |
Citation
Dessen P
GRM7 (glutamate metabotropic receptor 7)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64053/grm7-(glutamate-metabotropic-receptor-7)
