GRSF1 (G-rich RNA sequence binding factor 1)

2014-11-01  

Identity

HGNC
LOCATION
4q13.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 2926
MIM: 604851
HGNC: 4610
Ensembl: ENSG00000132463

Variants:

dbSNP: 2926
ClinVar: 2926
TCGA: ENSG00000132463
COSMIC: GRSF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000132463ENST00000254799Q12849
ENSG00000132463ENST00000499044H0YAK1
ENSG00000132463ENST00000502323Q12849
ENSG00000132463ENST00000502323A0A024RD99
ENSG00000132463ENST00000506453H0YAM1
ENSG00000132463ENST00000514161H0Y8R1
ENSG00000132463ENST00000545193F5H5I6

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50

Pathways

PathwaySourceExternal ID
DiseaseREACTOMER-HSA-1643685
Infectious diseaseREACTOMER-HSA-5663205
Influenza InfectionREACTOMER-HSA-168254
Influenza Life CycleREACTOMER-HSA-168255
Influenza Viral RNA Transcription and ReplicationREACTOMER-HSA-168273
Viral mRNA TranslationREACTOMER-HSA-192823

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
388193772024GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells.0
388193772024GRSF1 deficiency attenuates mitochondrial function in aging granulosa cells.0
379237342023GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.0
379237342023GRSF1 antagonizes age-associated hypercoagulability via modulation of fibrinogen mRNA stability.0
338132772021GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.6
338132772021GRSF1 promotes tumorigenesis and EMT-mediated metastasis through PI3K/AKT pathway in gastric cancer.6
326454842020Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.6
326454842020Identification of the COMM-domain containing protein 1 as specific binding partner for the guanine-rich RNA sequence binding factor 1.6
307154862019Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.29
307536712019Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.16
309443852019GRSF1 is an age-related regulator of senescence.7
314747572019A novel miRNA identified in GRSF1 complex drives the metastasis via the PIK3R3/AKT/NF-κB and TIMP3/MMP9 pathways in cervical cancer cells.24
307154862019Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.29
307536712019Loss of RNA-binding protein GRSF1 activates mTOR to elicit a proinflammatory transcriptional program.16
309443852019GRSF1 is an age-related regulator of senescence.7

Citation

Dessen P

GRSF1 (G-rich RNA sequence binding factor 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64059/grsf1-(g-rich-rna-sequence-binding-factor-1)