GTF3C1 (general transcription factor IIIC subunit 1)

2014-11-01  

Identity

HGNC
LOCATION
16p12.1
LOCUSID
ALIAS
TFIIIC,TFIIIC220,TFIIICalpha
FUSION GENES

Other Information

Locus ID:

NCBI: 2975
MIM: 603246
HGNC: 4664
Ensembl: ENSG00000077235

Variants:

dbSNP: 2975
ClinVar: 2975
TCGA: ENSG00000077235
COSMIC: GTF3C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000077235ENST00000356183Q12789
ENSG00000077235ENST00000561623Q12789
ENSG00000077235ENST00000564664H3BU55
ENSG00000077235ENST00000568569H3BRD0
ENSG00000077235ENST00000569653H3BU37
ENSG00000077235ENST00000571886I3L1Z3

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA Polymerase I, RNA Polymerase III, and Mitochondrial TranscriptionREACTOMER-HSA-504046
RNA Polymerase III TranscriptionREACTOMER-HSA-74158
RNA Polymerase III Abortive And Retractive InitiationREACTOMER-HSA-749476
RNA Polymerase III Transcription InitiationREACTOMER-HSA-76046
RNA Polymerase III Transcription Initiation From Type 1 PromoterREACTOMER-HSA-76061
RNA Polymerase III Transcription Initiation From Type 2 PromoterREACTOMER-HSA-76066

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379636032024The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.1
379636032024The Largest Subunit of Human TFIIIC Complex, TFIIIC220, a Lysine Acetyltransferase Targets Histone H3K18.1
368350382023TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.3
377619332023The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.1
368350382023TFIIIC as a Potential Epigenetic Modulator of Histone Acetylation in Human Stem Cells.3
377619332023The Conserved Chromatin Remodeler SMARCAD1 Interacts with TFIIIC and Architectural Proteins in Human and Mouse.1
239668772013Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.46
239668772013Binding of TFIIIC to sine elements controls the relocation of activity-dependent neuronal genes to transcription factories.46
205431382010mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.115
205431382010mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.115
186448732008Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.22
186448732008Different functional modes of p300 in activation of RNA polymerase III transcription from chromatin templates.22
174093852007Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.25
174093852007Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC.25
117419932002The activity of transcription factor IIIC1 is impaired during differentiation of F9 cells.3

Citation

Dessen P

GTF3C1 (general transcription factor IIIC subunit 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64094/gtf3c1-(general-transcription-factor-iiic-subunit-1)