GUCA2B (guanylate cyclase activator 2B)

2014-11-01  

Identity

HGNC
GUCA2B
LOCATION
1p34.2
LOCUSID
2981
ALIAS
GCAP-II,UGN
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2981
MIM: 601271
HGNC: 4683
Ensembl: ENSG00000044012

Variants:

dbSNP: 2981
ClinVar: 2981
TCGA: ENSG00000044012
COSMIC: GUCA2B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000044012ENST00000372581Q16661

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Miscellaneous digestion eventsREACTOMER-HSA-8935690

References

Pubmed IDYearTitleCitations
349907112022High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy.3
349907112022High plasma and lingual uroguanylin as potential contributors to changes in food preference after sleeve gastrectomy.3
288472132018Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.9
291120822018Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.8
292896972018Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.7
302669142018Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.2
288472132018Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.9
291120822018Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.8
292896972018Guanylin and uroguanylin mRNA expression is increased following Roux-en-Y gastric bypass, but guanylins do not play a significant role in body weight regulation and glycemic control.7
302669142018Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.2
270442582016Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.28
271088122016Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.17
271252482016Expression of guanylate cyclase-C, guanylin, and uroguanylin is downregulated proportionally to the ulcerative colitis disease activity index.23
276206672016Structural impact analysis of missense SNPs present in the uroguanylin gene by long-term molecular dynamics simulations.1
270442582016Cellular localization of guanylin and uroguanylin mRNAs in human and rat duodenal and colonic mucosa.28

Citation

Dessen P

GUCA2B (guanylate cyclase activator 2B)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64113/guca2b-(guanylate-cyclase-activator-2b)