HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)
2014-11-01 Affiliation
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 10021
MIM: 605206
HGNC: 16882
Ensembl: ENSG00000138622
Variants:
dbSNP: 10021
ClinVar: 10021
TCGA: ENSG00000138622
COSMIC: HCN4
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000138622 | ENST00000261917 | Q9Y3Q4 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38032931 | 2023 | A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family. | 4 |
| 38032931 | 2023 | A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family. | 4 |
| 35219649 | 2022 | Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel. | 1 |
| 35328031 | 2022 | Clinical Presentation of Left Ventricular Noncompaction Cardiomyopathy and Bradycardia in Three Families Carrying HCN4 Pathogenic Variants. | 6 |
| 35365232 | 2022 | Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes. | 2 |
| 35864219 | 2022 | Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. | 6 |
| 36244448 | 2022 | Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. | 2 |
| 35219649 | 2022 | Altered cyclic nucleotide binding and pore opening in a diseased human HCN4 channel. | 1 |
| 35328031 | 2022 | Clinical Presentation of Left Ventricular Noncompaction Cardiomyopathy and Bradycardia in Three Families Carrying HCN4 Pathogenic Variants. | 6 |
| 35365232 | 2022 | Enhancement of pacing function by HCN4 overexpression in human pluripotent stem cell-derived cardiomyocytes. | 2 |
| 35864219 | 2022 | Virus-induced inhibition of cardiac pacemaker channel HCN4 triggers bradycardia in human-induced stem cell system. | 6 |
| 36244448 | 2022 | Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation. | 2 |
| 34088380 | 2021 | Phenotype/Genotype Relationship in Left Ventricular Noncompaction: Ion Channel Gene Mutations Are Associated With Preserved Left Ventricular Systolic Function and Biventricular Noncompaction: Phenotype/Genotype of Noncompaction. | 8 |
| 34166608 | 2021 | Gating movements and ion permeation in HCN4 pacemaker channels. | 37 |
| 34088380 | 2021 | Phenotype/Genotype Relationship in Left Ventricular Noncompaction: Ion Channel Gene Mutations Are Associated With Preserved Left Ventricular Systolic Function and Biventricular Noncompaction: Phenotype/Genotype of Noncompaction. | 8 |
Citation
Dessen P
HCN4 (hyperpolarization activated cyclic nucleotide gated potassium channel 4)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64211/hcn4-(hyperpolarization-activated-cyclic-nucleotide-gated-potassium-channel-4)
