HDDC3 (HD domain containing 3)

2014-11-01  

Identity

HGNC
HDDC3
LOCATION
15q26.1
LOCUSID
374659
ALIAS
(ppGpp)ase,MESH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 374659
HGNC: 30522
Ensembl: ENSG00000184508

Variants:

dbSNP: 374659
ClinVar: 374659
TCGA: ENSG00000184508
COSMIC: HDDC3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000184508ENST00000330334Q8N4P3
ENSG00000184508ENST00000394272Q8N4P3
ENSG00000184508ENST00000559898H0YNP9
ENSG00000184508ENST00000561036H0YKT9
ENSG00000184508ENST00000646620Q8N4P3

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324621122020MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.71
324621122020MESH1 is a cytosolic NADPH phosphatase that regulates ferroptosis.71
208183902010A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.60
208183902010A metazoan ortholog of SpoT hydrolyzes ppGpp and functions in starvation responses.60

Citation

Dessen P

HDDC3 (HD domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64214/hddc3-(hd-domain-containing-3)