HECTD1 (HECT domain E3 ubiquitin protein ligase 1)

2014-11-01  

Identity

HGNC
LOCATION
14q12
LOCUSID
ALIAS
EULIR
FUSION GENES

Other Information

Locus ID:

NCBI: 25831
MIM: 618649
HGNC: 20157
Ensembl: ENSG00000092148

Variants:

dbSNP: 25831
ClinVar: 25831
TCGA: ENSG00000092148
COSMIC: HECTD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000092148ENST00000399332Q9ULT8
ENSG00000092148ENST00000553700Q9ULT8
ENSG00000092148ENST00000553957H0YJP0
ENSG00000092148ENST00000554471A0A087WVU6
ENSG00000092148ENST00000554882H0YJD4
ENSG00000092148ENST00000555915H0YJ72
ENSG00000092148ENST00000556224G3V4V5
ENSG00000092148ENST00000557369H0YJV8
ENSG00000092148ENST00000611816A0A087X2H1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Class I MHC mediated antigen processing & presentationREACTOMER-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradationREACTOMER-HSA-983168

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
379937502024Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.0
384512912024Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects.0
379937502024Nucleoporin 93, a new substrate of the E3 ubiquitin protein ligase HECTD1, promotes esophageal squamous cell carcinoma progression.0
384512912024Identification and functional analysis of rare HECTD1 missense variants in human neural tube defects.0
359152032022The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.6
359152032022The E3 ubiquitin ligase HECTD1 contributes to cell proliferation through an effect on mitosis.6
335613152021Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.9
338537582021The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.12
335613152021Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.9
338537582021The deubiquitinase TRABID stabilizes the K29/K48-specific E3 ubiquitin ligase HECTD1.12
317996322020HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.12
323195762020HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition.14
326757462020CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism.11
317996322020HECTD1 promotes base excision repair in nucleosomes through chromatin remodelling.12
323195762020HECTD1 regulates the expression of SNAIL: Implications for epithelial‑mesenchymal transition.14

Citation

Dessen P

HECTD1 (HECT domain E3 ubiquitin protein ligase 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64227/js/lib/welcome