HOXD4 (homeobox D4)

2014-11-01 Affiliation

Identity

HGNC

HOXD4

LOCATION

2q31.1

LOCUSID

3233

ALIAS

HHO.C13,HOX-5.1,HOX4,HOX4B,Hox-4.2

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 3233
MIM: 142981
HGNC: 5138
Ensembl: ENSG00000170166

Variants:

dbSNP: 3233
ClinVar: 3233
TCGA: ENSG00000170166
COSMIC: HOXD4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000170166	ENST00000306324	P09016

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Developmental Biology	REACTOME	R-HSA-1266738
Activation of HOX genes during differentiation	REACTOME	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	REACTOME	R-HSA-5617472

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37827698	2023	A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma.	0
37827698	2023	A pan-cancer analysis of the role of HOXD1, HOXD3, and HOXD4 and validation in renal cell carcinoma.	0
26545093	2015	Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.	8
26545093	2015	Identification of HOXD4 Mutations in Spinal Extradural Arachnoid Cyst.	8
20686522	2010	Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.	7
20686522	2010	Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.	7
20686522	2010	Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.	7
20686522	2010	Polymorphisms in the HOXD4 gene are not associated with peak bone mineral density in Chinese nuclear families.	7
19232136	2009	Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells.	87
19453261	2009	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	23
19938081	2009	Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.	17
19232136	2009	Transcriptional inhibiton of Hoxd4 expression by miRNA-10a in human breast cancer cells.	87
19453261	2009	High-density association study of 383 candidate genes for volumetric BMD at the femoral neck and lumbar spine among older men.	23
19938081	2009	Altered transmission of HOX and apoptotic SNPs identify a potential common pathway for clubfoot.	17
15776434	2005	Mutation analysis of the HOX paralogous 4-13 genes in children with acute lymphoid malignancies: identification of a novel germline mutation of HOXD4 leading to a partial loss-of-function.	9

Citation

Dessen P

HOXD4 (homeobox D4)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64403/hoxd4-(homeobox-d4)