Identity
HGNC
LOCATION
12q24.31
LOCUSID
ALIAS
4-HPPD,4HPPD,GLOD3,HPPDASE,PPD
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3242
MIM: 609695
HGNC: 5147
Ensembl: ENSG00000158104
Variants:
dbSNP: 3242
ClinVar: 3242
TCGA: ENSG00000158104
COSMIC: HPD
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158104 | ENST00000289004 | A0A0B4J1R4 |
| ENSG00000158104 | ENST00000543163 | P32754 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 34471290 | 2021 | The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. | 15 |
| 34471290 | 2021 | The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway. | 15 |
| 31722428 | 2020 | Role of the N-terminus in human 4-hydroxyphenylpyruvate dioxygenase activity. | 0 |
| 32109208 | 2020 | Variant analysis of HPD genes from two families showing elevated tyrosine upon newborn screening by tandem mass spectrometry (MS/MS). | 3 |
| 32891822 | 2020 | Tyrosine metabolic enzyme HPD is decreased and predicts unfavorable outcomes in hepatocellular carcinoma. | 3 |
| 31722428 | 2020 | Role of the N-terminus in human 4-hydroxyphenylpyruvate dioxygenase activity. | 0 |
| 32109208 | 2020 | Variant analysis of HPD genes from two families showing elevated tyrosine upon newborn screening by tandem mass spectrometry (MS/MS). | 3 |
| 32891822 | 2020 | Tyrosine metabolic enzyme HPD is decreased and predicts unfavorable outcomes in hepatocellular carcinoma. | 3 |
| 31277952 | 2019 | HPD overexpression predicts poor prognosis in breast cancer. | 3 |
| 31285420 | 2019 | 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. | 29 |
| 31277952 | 2019 | HPD overexpression predicts poor prognosis in breast cancer. | 3 |
| 31285420 | 2019 | 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. | 29 |
| 26226126 | 2016 | Hawkinsinuria in two unrelated Greek newborns: identification of a novel variant, biochemical findings and treatment. | 4 |
| 26936969 | 2016 | The different catalytic roles of the metal-binding ligands in human 4-hydroxyphenylpyruvate dioxygenase. | 4 |
| 26226126 | 2016 | Hawkinsinuria in two unrelated Greek newborns: identification of a novel variant, biochemical findings and treatment. | 4 |
Citation
Dessen P
HPD (4-hydroxyphenylpyruvate dioxygenase)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64413/gene-fusions/meetings/
