Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9177
MIM: 604654
HGNC: 5298
Ensembl: ENSG00000149305
Variants:
dbSNP: 9177
ClinVar: 9177
TCGA: ENSG00000149305
COSMIC: HTR3B
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000149305 | ENST00000260191 | O95264 |
| ENSG00000149305 | ENST00000537778 | O95264 |
| ENSG00000149305 | ENST00000543092 | H0YFX8 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10352 | palonosetron | Chemical | VariantAnnotation | not associated | PD | 29177570 | |
| PA157379134 | Myalgia unspecified | Disease | ClinicalAnnotation | associated | PD | 17600820 | |
| PA444460 | Heroin Dependence | Disease | ClinicalAnnotation | associated | PD | ||
| PA445048 | Nausea | Disease | VariantAnnotation | not associated | PD | 29177570, 29546524 | |
| PA445062 | Neoplasms | Disease | VariantAnnotation | not associated | PD | 29546524 | |
| PA445208 | Pain | Disease | VariantAnnotation | not associated | PD | 21398039 | |
| PA445876 | Tobacco Use Disorder | Disease | ClinicalAnnotation | associated | PD | ||
| PA446051 | Vomiting | Disease | VariantAnnotation | not associated | PD | 29177570, 29546524 | |
| PA447208 | Mental Disorders | Disease | ClinicalAnnotation | associated | PK | PD | 16534507, 20075642 |
| PA448500 | atorvastatin | Chemical | ClinicalAnnotation | associated | PD | 17600820 | |
| PA449809 | granisetron | Chemical | VariantAnnotation | not associated | PD | 29177570 | |
| PA450626 | nicotine | Chemical | ClinicalAnnotation | associated | PD | ||
| PA450801 | paroxetine | Chemical | ClinicalAnnotation | associated | PK | PD | 16534507, 20075642 |
| PA451089 | pravastatin | Chemical | ClinicalAnnotation | associated | PD | 17600820 | |
| PA451363 | simvastatin | Chemical | ClinicalAnnotation | associated | PD | 17600820 | |
| PA452618 | opioids | Chemical | VariantAnnotation | not associated | PD | 21398039 | |
| PA452619 | heroin | Chemical | ClinicalAnnotation | associated | PD | ||
| PA452621 | antineoplastic agents | Chemical | VariantAnnotation | not associated | PD | 29546524 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 36849934 | 2023 | Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study. | 0 |
| 36849934 | 2023 | Association of HTR3B gene polymorphisms with depression and its executive dysfunction: a case-control study. | 0 |
| 33605481 | 2021 | Polymorphisms of 5-hydroxytryptamine receptor type 3B gene and clinical characteristics for vomiting after breast surgery in chinese han female population. | 1 |
| 34948773 | 2021 | The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility. | 1 |
| 33605481 | 2021 | Polymorphisms of 5-hydroxytryptamine receptor type 3B gene and clinical characteristics for vomiting after breast surgery in chinese han female population. | 1 |
| 34948773 | 2021 | The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility. | 1 |
| 29885172 | 2018 | Association of anti-emetic efficacy of Ondansetron with 18792A>G polymorphism in a drug target gene 5-HT3B in Pakistani population. | 0 |
| 30405098 | 2018 | Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers. | 6 |
| 29885172 | 2018 | Association of anti-emetic efficacy of Ondansetron with 18792A>G polymorphism in a drug target gene 5-HT3B in Pakistani population. | 0 |
| 30405098 | 2018 | Association and cis-mQTL analysis of variants in serotonergic genes associated with nicotine dependence in Chinese Han smokers. | 6 |
| 27488933 | 2017 | Effect of the allelic variants of ABCB1, CYP2D6 and HTR3B on response of ramosetron to prevent chemotherapy-induced nausea and vomiting in Korean cancer patients. | 5 |
| 27488933 | 2017 | Effect of the allelic variants of ABCB1, CYP2D6 and HTR3B on response of ramosetron to prevent chemotherapy-induced nausea and vomiting in Korean cancer patients. | 5 |
| 27616601 | 2016 | Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression. | 5 |
| 27706728 | 2016 | Associations of serotonin receptor gene HTR3A, HTR3B, and HTR3A haplotypes with bipolar disorder in Chinese patients. | 2 |
| 27773795 | 2016 | Polymorphisms in the 5-hydroxytryptamine receptor 3B gene are associated with heroin dependence in the Chinese Han population. | 2 |
Citation
Dessen P
HTR3B (5-hydroxytryptamine receptor 3B)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64468/htr3b-(5-hydroxytryptamine-receptor-3b)
