HTR5A (5-hydroxytryptamine receptor 5A)

2014-11-01  

Identity

HGNC
LOCATION
7q36.2
LOCUSID
ALIAS
5-HT5A

Other Information

Locus ID:

NCBI: 3361
MIM: 601305
HGNC: 5300
Ensembl: ENSG00000157219

Variants:

dbSNP: 3361
ClinVar: 3361
TCGA: ENSG00000157219
COSMIC: HTR5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000157219ENST00000287907P47898
ENSG00000157219ENST00000287907A4D2N2
ENSG00000157219ENST00000649716A0A3B3ISH0

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Serotonergic synapseKEGGhsa04726
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Amine ligand-binding receptorsREACTOMER-HSA-375280
Serotonin receptorsREACTOMER-HSA-390666
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
3254975820205-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion.10
3254975820205-HT receptor agonist Valerenic Acid enhances the innate immunity signal and suppresses glioblastoma cell growth and invasion.10
278972662016Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.24
278972662016Evaluation of association of common variants in HTR1A and HTR5A with schizophrenia and executive function.24
249037722014Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.0
249037722014Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression.0
193811542010Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.26
193811542010Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.26
194556002010Association study of the serotoninergic system in migraine in the Spanish population.15
203888412010Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.10
203888412010Serotonin (5-HT) receptor 5A sequence variants affect human plasma triglyceride levels.10
204680642010Association study of 182 candidate genes in anorexia nervosa.32
207340642010A large-scale candidate gene association study of age at menarche and age at natural menopause.57
193811542010Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.26
193811542010Differences and similarities in the serotonergic diathesis for suicide attempts and mood disorders: a 22-year longitudinal gene-environment study.26

Citation

Dessen P

HTR5A (5-hydroxytryptamine receptor 5A)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64472/htr5a-(5-hydroxytryptamine-receptor-5a)