Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3362
MIM: 601109
HGNC: 5301
Ensembl: ENSG00000158748
Variants:
dbSNP: 3362
ClinVar: 3362
TCGA: ENSG00000158748
COSMIC: HTR6
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000158748 | ENST00000289753 | P50406 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA175 | GNAS | Gene | Pathway | associated | 19741567 | ||
| PA444545 | Hyperprolactinemia | Disease | VariantAnnotation | associated | PD | 19997080 | |
| PA447198 | Autistic Disorder | Disease | VariantAnnotation | associated | PD | 19997080 | |
| PA451257 | risperidone | Chemical | VariantAnnotation | associated | PD | 19997080 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38086448 | 2024 | Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension. | 1 |
| 38086448 | 2024 | Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension. | 1 |
| 35359970 | 2022 | Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment. | 0 |
| 35359970 | 2022 | Systematic Analysis of Neurotransmitter Receptors in Human Breast Cancer Reveals a Strong Association With Outcome and Uncovers HTR6 as a Survival-Associated Gene Potentially Regulating the Immune Microenvironment. | 0 |
| 33357407 | 2021 | Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors. | 8 |
| 33372037 | 2021 | HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. | 13 |
| 34003104 | 2021 | [5-HT(6) receptor-mTOR: An hyperactive couple in neuropathic pain]. | 0 |
| 33357407 | 2021 | Constitutive Activity of Serotonin Receptor 6 Regulates Human Cerebral Organoids Formation and Depression-like Behaviors. | 8 |
| 33372037 | 2021 | HTR6 and SSTR3 ciliary targeting relies on both IC3 loops and C-terminal tails. | 13 |
| 34003104 | 2021 | [5-HT(6) receptor-mTOR: An hyperactive couple in neuropathic pain]. | 0 |
| 31587366 | 2020 | Correlation of 5-HTR6 gene polymorphism with vestibular migraine. | 4 |
| 32417774 | 2020 | Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P. | 1 |
| 31587366 | 2020 | Correlation of 5-HTR6 gene polymorphism with vestibular migraine. | 4 |
| 32417774 | 2020 | Change in Expression of 5-HT6 Receptor at Different Stages of Alzheimer's Disease: A Postmortem Study with the PET Radiopharmaceutical [18F]2FNQ1P. | 1 |
| 25034463 | 2015 | 5-HT6 Receptor Recruitment of mTOR Modulates Seizure Activity in Epilepsy. | 8 |
Citation
Dessen P
HTR6 (5-hydroxytryptamine receptor 6)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64474/htr6-(5-hydroxytryptamine-receptor-6)
