Identity
HGNC
LOCATION
15q15.3
LOCUSID
ALIAS
C15orf63,HSPC136
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 25764
MIM: 612784
HGNC: 18418
Ensembl: ENSG00000242028
Variants:
dbSNP: 25764
ClinVar: 25764
TCGA: ENSG00000242028
COSMIC: HYPK
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000242028 | ENST00000406925 | Q9NX55 |
| ENSG00000242028 | ENST00000442995 | Q9NX55 |
| ENSG00000242028 | ENST00000458412 | J3QT56 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38657047 | 2024 | HYPK: A marginally disordered protein sensitive to charge decoration. | 0 |
| 38657047 | 2024 | HYPK: A marginally disordered protein sensitive to charge decoration. | 0 |
| 34836490 | 2022 | HYPK coordinates degradation of polyneddylated proteins by autophagy. | 7 |
| 35857868 | 2022 | Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. | 3 |
| 34836490 | 2022 | HYPK coordinates degradation of polyneddylated proteins by autophagy. | 7 |
| 35857868 | 2022 | Phosphorylation of Arl4A/D promotes their binding by the HYPK chaperone for their stable recruitment to the plasma membrane. | 3 |
| 32042062 | 2020 | Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. | 20 |
| 32042062 | 2020 | Molecular basis for N-terminal acetylation by human NatE and its modulation by HYPK. | 20 |
| 31397627 | 2019 | An IRES-dependent translation of HYPK mRNA generates a truncated isoform of the protein that lacks the nuclear localization and functional ability. | 3 |
| 31397627 | 2019 | An IRES-dependent translation of HYPK mRNA generates a truncated isoform of the protein that lacks the nuclear localization and functional ability. | 3 |
| 29381348 | 2018 | Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation. | 10 |
| 29754825 | 2018 | Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. | 37 |
| 30251673 | 2018 | Metastable states of HYPK-UBA domain's seeds drive the dynamics of its own aggregation. | 6 |
| 29381348 | 2018 | Disordered Nanostructure in Huntingtin Interacting Protein K Acts as a Stabilizing Switch To Prevent Protein Aggregation. | 10 |
| 29754825 | 2018 | Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. | 37 |
Citation
Dessen P
HYPK (huntingtin interacting protein K)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64482/hypk-(huntingtin-interacting-protein-k)
