Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3382
MIM: 147625
HGNC: 5343
Ensembl: ENSG00000003147
Variants:
dbSNP: 3382
ClinVar: 3382
TCGA: ENSG00000003147
COSMIC: ICA1
RNA/Proteins
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Type I diabetes mellitus | KEGG | ko04940 |
| Type I diabetes mellitus | KEGG | hsa04940 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA166131379 | o-desmethyltramadol | Chemical | ClinicalAnnotation | associated | PK | 30971809 | |
| PA451735 | tramadol | Chemical | ClinicalAnnotation | associated | PK | 30971809 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 31478943 | 2020 | Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior. | 7 |
| 31478943 | 2020 | Novel SRF-ICA1L Fusions in Cellular Myoid Neoplasms With Potential For Malignant Behavior. | 7 |
| 23836780 | 2013 | Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. | 19 |
| 24358315 | 2013 | C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity. | 9 |
| 23836780 | 2013 | Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus. | 19 |
| 24358315 | 2013 | C-terminal domain of ICA69 interacts with PICK1 and acts on trafficking of PICK1-PKCα complex and cerebellar plasticity. | 9 |
| 22447927 | 2012 | Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. | 10 |
| 22447927 | 2012 | Sequence variation in promoter of Ica1 gene, which encodes protein implicated in type 1 diabetes, causes transcription factor autoimmune regulator (AIRE) to increase its binding and down-regulate expression. | 10 |
| 20962850 | 2011 | A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. | 25 |
| 20962850 | 2011 | A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles. | 25 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20526340 | 2010 | Common variants in FOXP1 are associated with generalized vitiligo. | 32 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
| 20526340 | 2010 | Common variants in FOXP1 are associated with generalized vitiligo. | 32 |
| 18187231 | 2008 | ICA69 is a novel Rab2 effector regulating ER-Golgi trafficking in insulinoma cells. | 32 |
Citation
Dessen P
ICA1 (islet cell autoantigen 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64489
