IFT140 (intraflagellar transport 140)

2014-11-01  

Identity

HGNC
LOCATION
16p13.3
LOCUSID
ALIAS
MZSDS,RP80,SRTD9,WDTC2,c305C8.4,c380F5.1,gs114
FUSION GENES

Other Information

Locus ID:

NCBI: 9742
MIM: 614620
HGNC: 29077
Ensembl: ENSG00000187535

Variants:

dbSNP: 9742
ClinVar: 9742
TCGA: ENSG00000187535
COSMIC: IFT140

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000187535ENST00000361339Q96RY7
ENSG00000187535ENST00000397417J3KPW0
ENSG00000187535ENST00000426508Q96RY7
ENSG00000187535ENST00000568837I3L0Y8
ENSG00000187535ENST00000569646H3BNC5
ENSG00000187535ENST00000569812H3BTA5

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Intraflagellar transportREACTOMER-HSA-5620924
Signal TransductionREACTOMER-HSA-162582
Signaling by HedgehogREACTOMER-HSA-5358351
Hedgehog 'off' stateREACTOMER-HSA-5610787

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378447242024Monoallelic Loss-of-Function IFT140 Pathogenic Variants Cause Autosomal Dominant Polycystic Kidney Disease: A Confirmatory Study With Suspicion of an Additional Cardiac Phenotype.2
378447242024Monoallelic Loss-of-Function IFT140 Pathogenic Variants Cause Autosomal Dominant Polycystic Kidney Disease: A Confirmatory Study With Suspicion of an Additional Cardiac Phenotype.2
348905462022Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype.49
348905462022Monoallelic IFT140 pathogenic variants are an important cause of the autosomal dominant polycystic kidney-spectrum phenotype.49
310343132019The Role of IFT140 in Osteogenesis of Adult Mice Long Bone.10
313970982019Novel IFT140 variants cause spermatogenic dysfunction in humans.11
310343132019The Role of IFT140 in Osteogenesis of Adult Mice Long Bone.10
313970982019Novel IFT140 variants cause spermatogenic dysfunction in humans.11
291118612018Compound heterozygous variants in IFT140 as a cause of nonsyndromic retinitis pigmentosa.0
296885942018Whole-genome sequencing in patients with ciliopathies uncovers a novel recurrent tandem duplication in IFT140.10
291118612018Compound heterozygous variants in IFT140 as a cause of nonsyndromic retinitis pigmentosa.0
296885942018Whole-genome sequencing in patients with ciliopathies uncovers a novel recurrent tandem duplication in IFT140.10
278741742017Compound heterozygous mutations in the IFT140 gene cause Opitz trigonocephaly C syndrome in a patient with typical features of a ciliopathy.10
287243972017Partial uniparental isodisomy of chromosome 16 unmasks a deleterious biallelic mutation in IFT140 that causes Mainzer-Saldino syndrome.10
278741742017Compound heterozygous mutations in the IFT140 gene cause Opitz trigonocephaly C syndrome in a patient with typical features of a ciliopathy.10

Citation

Dessen P

IFT140 (intraflagellar transport 140)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64530/ift140-(intraflagellar-transport-140)