Identity
HGNC
LOCATION
2q12.1
LOCUSID
ALIAS
IL-1Rrp2,IL-36R,IL1R-rp2,IL1RRP2
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 8808
MIM: 604512
HGNC: 5999
Ensembl: ENSG00000115598
Variants:
dbSNP: 8808
ClinVar: 8808
TCGA: ENSG00000115598
COSMIC: IL1RL2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000115598 | ENST00000264257 | Q9HB29 |
| ENSG00000115598 | ENST00000421464 | C9K0I8 |
| ENSG00000115598 | ENST00000441515 | Q9HB29 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Immune System | REACTOME | R-HSA-168256 |
| Cytokine Signaling in Immune system | REACTOME | R-HSA-1280215 |
| Signaling by Interleukins | REACTOME | R-HSA-449147 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38189700 | 2024 | Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases. | 2 |
| 38189700 | 2024 | Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases. | 2 |
| 36482185 | 2023 | Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis. | 3 |
| 37414245 | 2023 | In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex. | 0 |
| 36482185 | 2023 | Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis. | 3 |
| 37414245 | 2023 | In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex. | 0 |
| 35171706 | 2022 | Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications. | 4 |
| 36525507 | 2022 | Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. | 2 |
| 35171706 | 2022 | Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications. | 4 |
| 36525507 | 2022 | Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement. | 2 |
| 33034926 | 2021 | Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation. | 8 |
| 33034926 | 2021 | Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation. | 8 |
| 27673278 | 2017 | IL-36γ has proinflammatory effects on human endothelial cells. | 34 |
| 27853811 | 2017 | Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease. | 6 |
| 27673278 | 2017 | IL-36γ has proinflammatory effects on human endothelial cells. | 34 |
Citation
Dessen P
IL1RL2 (interleukin 1 receptor like 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64594/il1rl2-(interleukin-1-receptor-like-2)
