IL1RL2 (interleukin 1 receptor like 2)

2014-11-01  

Identity

HGNC
IL1RL2
LOCATION
2q12.1
LOCUSID
8808
ALIAS
IL-1Rrp2,IL-36R,IL1R-rp2,IL1RRP2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8808
MIM: 604512
HGNC: 5999
Ensembl: ENSG00000115598

Variants:

dbSNP: 8808
ClinVar: 8808
TCGA: ENSG00000115598
COSMIC: IL1RL2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115598ENST00000264257Q9HB29
ENSG00000115598ENST00000421464C9K0I8
ENSG00000115598ENST00000441515Q9HB29

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381897002024Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.2
381897002024Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases.2
364821852023Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.3
374142452023In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.0
364821852023Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis.3
374142452023In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex.0
351717062022Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.4
365255072022Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.2
351717062022Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications.4
365255072022Myeloid cell-derived proteases produce a proinflammatory form of IL-37 that signals via IL-36 receptor engagement.2
330349262021Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.8
330349262021Serum IL-36 cytokines levels in type 2 diabetes mellitus patients and their association with obesity, insulin resistance, and inflammation.8
276732782017IL-36γ has proinflammatory effects on human endothelial cells.34
278538112017Altered expression of IL36γ and IL36 receptor (IL1RL2) in the colon of patients with Hirschsprung's disease.6
276732782017IL-36γ has proinflammatory effects on human endothelial cells.34

Citation

Dessen P

IL1RL2 (interleukin 1 receptor like 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64594/il1rl2-(interleukin-1-receptor-like-2)