INTS8 (integrator complex subunit 8)

2014-11-01  

Identity

HGNC
INTS8
LOCATION
8q22.1
LOCUSID
55656
ALIAS
C8orf52,INT8,NEDCHS
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55656
MIM: 611351
HGNC: 26048
Ensembl: ENSG00000164941

Variants:

dbSNP: 55656
ClinVar: 55656
TCGA: ENSG00000164941
COSMIC: INTS8

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000164941ENST00000343161J3KNV5
ENSG00000164941ENST00000519053E5RJL5
ENSG00000164941ENST00000519457E5RJF0
ENSG00000164941ENST00000520315H0YC12
ENSG00000164941ENST00000520526H0YBS1
ENSG00000164941ENST00000521860H0YBQ1
ENSG00000164941ENST00000522171E5RIN8
ENSG00000164941ENST00000523206E5RG48
ENSG00000164941ENST00000523731Q75QN2
ENSG00000164941ENST00000523808E5RH10
ENSG00000164941ENST00000524333E5RG48

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
RNA polymerase II transcribes snRNA genesREACTOMER-HSA-6807505

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348803282021INTS8 is a therapeutic target for intrahepatic cholangiocarcinoma via the integration of bioinformatics analysis and experimental validation.2
348803282021INTS8 is a therapeutic target for intrahepatic cholangiocarcinoma via the integration of bioinformatics analysis and experimental validation.2
329667592020Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.69
329667592020Integrator Recruits Protein Phosphatase 2A to Prevent Pause Release and Facilitate Transcription Termination.69
285421702017Human mutations in integrator complex subunits link transcriptome integrity to brain development.51
285421702017Human mutations in integrator complex subunits link transcriptome integrity to brain development.51
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

INTS8 (integrator complex subunit 8)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64632/ints8-(integrator-complex-subunit-8)