Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 122961
MIM: 615317
HGNC: 19857
Ensembl: ENSG00000165898
Variants:
dbSNP: 122961
ClinVar: 122961
TCGA: ENSG00000165898
COSMIC: ISCA2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000165898 | ENST00000298818 | J3QSS7 |
| ENSG00000165898 | ENST00000554924 | Q86U28 |
| ENSG00000165898 | ENST00000556816 | Q86U28 |
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37225108 | 2023 | Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins. | 2 |
| 37225108 | 2023 | Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins. | 2 |
| 35714932 | 2022 | ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation. | 3 |
| 36097192 | 2022 | ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. | 13 |
| 35714932 | 2022 | ISCA2 deficiency leads to heme synthesis defects and impaired erythroid differentiation in K562 cells by indirect ROS-mediated IRP1 activation. | 3 |
| 36097192 | 2022 | ISCA2 inhibition decreases HIF and induces ferroptosis in clear cell renal carcinoma. | 13 |
| 33562493 | 2021 | Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly. | 11 |
| 33711344 | 2021 | ISCA1 Orchestrates ISCA2 and NFU1 in the Maturation of Human Mitochondrial [4Fe-4S] Proteins. | 6 |
| 33562493 | 2021 | Characterization and Reconstitution of Human Lipoyl Synthase (LIAS) Supports ISCA2 and ISCU as Primary Cluster Donors and an Ordered Mechanism of Cluster Assembly. | 11 |
| 33711344 | 2021 | ISCA1 Orchestrates ISCA2 and NFU1 in the Maturation of Human Mitochondrial [4Fe-4S] Proteins. | 6 |
| 32424628 | 2020 | Expanding the genotype-phenotype spectrum of ISCA2-related multiple mitochondrial dysfunction syndrome-cavitating leukoencephalopathy and prolonged survival. | 7 |
| 32424628 | 2020 | Expanding the genotype-phenotype spectrum of ISCA2-related multiple mitochondrial dysfunction syndrome-cavitating leukoencephalopathy and prolonged survival. | 7 |
| 31831856 | 2019 | Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery. | 14 |
| 31831856 | 2019 | Structural properties of [2Fe-2S] ISCA2-IBA57: a complex of the mitochondrial iron-sulfur cluster assembly machinery. | 14 |
| 29297947 | 2018 | Loss-of-function mutations in ISCA2 disrupt 4Fe-4S cluster machinery and cause a fatal leukodystrophy with hyperglycinemia and mtDNA depletion. | 12 |
Citation
Dessen P
ISCA2 (iron-sulfur cluster assembly 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64668/isca2-(iron-sulfur-cluster-assembly-2)
