ISLR (immunoglobulin superfamily containing leucine rich repeat)

2014-11-01  

Identity

HGNC
ISLR
LOCATION
15q24.1
LOCUSID
3671
ALIAS
HsT17563,Meflin
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3671
MIM: 602059
HGNC: 6133
Ensembl: ENSG00000129009

Variants:

dbSNP: 3671
ClinVar: 3671
TCGA: ENSG00000129009
COSMIC: ISLR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000129009ENST00000249842O14498
ENSG00000129009ENST00000249842A0A146E5L3
ENSG00000129009ENST00000395118O14498
ENSG00000129009ENST00000395118A0A146E5L3
ENSG00000129009ENST00000559510H0YN67
ENSG00000129009ENST00000560862H0YL90

Expression (GTEx)

0
50
100
150
200
250
300
350
400
450
500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
377963862024Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.0
377963862024Meflin is a marker of pancreatic stellate cells involved in fibrosis and epithelial regeneration in the pancreas.0
331974482021The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.58
347133002021Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer.10
331974482021The Balance of Stromal BMP Signaling Mediated by GREM1 and ISLR Drives Colorectal Carcinogenesis.58
347133002021Silencing of ISLR inhibits tumour progression and glycolysis by inactivating the IL‑6/JAK/STAT3 pathway in non‑small cell lung cancer.10
321288392020Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.31
321288392020Secreted stromal protein ISLR promotes intestinal regeneration by suppressing epithelial Hippo signaling.31
314395482019Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.131
314395482019Meflin-Positive Cancer-Associated Fibroblasts Inhibit Pancreatic Carcinogenesis.131

Citation

Dessen P

ISLR (immunoglobulin superfamily containing leucine rich repeat)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64671/submit-meetings/new-content/