Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3713
MIM: 147360
HGNC: 6187
Ensembl: ENSG00000163207
Variants:
dbSNP: 3713
ClinVar: 3713
TCGA: ENSG00000163207
COSMIC: IVL
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000163207 | ENST00000368764 | P07476 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Developmental Biology | REACTOME | R-HSA-1266738 |
| Keratinization | REACTOME | R-HSA-6805567 |
| Formation of the cornified envelope | REACTOME | R-HSA-6809371 |
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA10004 | adalimumab | Chemical | VariantAnnotation | associated | PD | 29192552 | |
| PA445451 | Psoriasis | Disease | VariantAnnotation | associated | PD | 29192552 | |
| PA452639 | infliximab | Chemical | VariantAnnotation | associated | PD | 29192552 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32751111 | 2020 | Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis. | 112 |
| 32751111 | 2020 | Regulation of Filaggrin, Loricrin, and Involucrin by IL-4, IL-13, IL-17A, IL-22, AHR, and NRF2: Pathogenic Implications in Atopic Dermatitis. | 112 |
| 24252747 | 2014 | Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. | 2 |
| 24515279 | 2014 | Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner. | 5 |
| 24252747 | 2014 | Neuronatin is related to keratinocyte differentiation by up-regulating involucrin. | 2 |
| 24515279 | 2014 | Glucocorticoid receptor enhances involucrin expression of keratinocyte in a ligand-independent manner. | 5 |
| 23283814 | 2013 | Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3β. | 14 |
| 23599428 | 2013 | Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes. | 24 |
| 23283814 | 2013 | Regulation of involucrin in psoriatic epidermal keratinocytes: the roles of ERK1/2 and GSK-3β. | 14 |
| 23599428 | 2013 | Protein kinase C δ increases Kruppel-like factor 4 protein, which drives involucrin gene transcription in differentiating keratinocytes. | 24 |
| 22197495 | 2012 | Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair. | 2 |
| 22333115 | 2012 | Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes. | 12 |
| 22742591 | 2012 | The antimicrobial peptide pheromone Plantaricin A increases antioxidant defenses of human keratinocytes and modulates the expression of filaggrin, involucrin, β-defensin 2 and tumor necrosis factor-α genes. | 9 |
| 22197495 | 2012 | Ultrastructural immunolocalization of involucrin in the medulla and inner root sheath of the human hair. | 2 |
| 22333115 | 2012 | Effects of human papillomavirus (HPV) type 16 oncoproteins on the expression of involucrin in human keratinocytes. | 12 |
Citation
Dessen P
IVL (involucrin)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64702/ivl-(involucrin)
