JOSD2 (Josephin domain containing 2)

2014-11-01  

Identity

HGNC
LOCATION
19q13.33
LOCUSID
ALIAS
SBBI54
FUSION GENES

Other Information

Locus ID:

NCBI: 126119
MIM: 615324
HGNC: 28853
Ensembl: ENSG00000161677

Variants:

dbSNP: 126119
ClinVar: 126119
TCGA: ENSG00000161677
COSMIC: JOSD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000161677ENST00000594350M0QZL8
ENSG00000161677ENST00000595669Q8TAC2
ENSG00000161677ENST00000598418Q8TAC2
ENSG00000161677ENST00000598418A0A024R4G2
ENSG00000161677ENST00000601423Q8TAC2
ENSG00000161677ENST00000601423A0A024R4G2

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DeubiquitinationREACTOMER-HSA-5688426
Josephin domain DUBsREACTOMER-HSA-5689877

References

Pubmed IDYearTitleCitations
381771352024Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity.0
381771352024Josephin domain containing 2 (JOSD2) promotes lung cancer by inhibiting LKB1 (Liver kinase B1) activity.0
365838172023Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma.5
378993942023Deubiquitinating enzyme JOSD2 affects susceptibility of non-small cell lung carcinoma cells to anti-cancer drugs through DNA damage repair.1
365838172023Deubiquitinating enzyme Josephin-2 stabilizes PHGDH to promote a cancer stem cell phenotype in hepatocellular carcinoma.5
378993942023Deubiquitinating enzyme JOSD2 affects susceptibility of non-small cell lung carcinoma cells to anti-cancer drugs through DNA damage repair.1
355689702022Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation.6
355689702022Deubiquitinating enzyme JOSD2 promotes hepatocellular carcinoma progression through interacting with and inhibiting CTNNB1 degradation.6
330825142021The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.15
330825142021The deubiquitinase JOSD2 is a positive regulator of glucose metabolism.15

Citation

Dessen P

JOSD2 (Josephin domain containing 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64723/josd2-(josephin-domain-containing-2)