KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)

2014-11-01  

Identity

HGNC
LOCATION
11q13.4
LOCUSID
ALIAS
BRGDA6,HOKPP,HYPP,MiRP2
FUSION GENES

Other Information

Locus ID:

NCBI: 10008
MIM: 604433
HGNC: 6243
Ensembl: ENSG00000175538

Variants:

dbSNP: 10008
ClinVar: 10008
TCGA: ENSG00000175538
COSMIC: KCNE3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175538ENST00000310128Q9Y6H6
ENSG00000175538ENST00000310128Q6IAE6
ENSG00000175538ENST00000525550Q9Y6H6
ENSG00000175538ENST00000525550Q6IAE6
ENSG00000175538ENST00000526855E9PJQ7
ENSG00000175538ENST00000529425E9PN03
ENSG00000175538ENST00000531854E9PJV9
ENSG00000175538ENST00000532569Q2N1I1

Expression (GTEx)

0
5
10
15
20

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 2 - plateau phaseREACTOMER-HSA-5576893
Phase 3 - rapid repolarisationREACTOMER-HSA-5576890

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
357167252022Comparing the structural dynamics of the human KCNE3 in reconstituted micelle and lipid bilayered vesicle environments.2
357167252022Comparing the structural dynamics of the human KCNE3 in reconstituted micelle and lipid bilayered vesicle environments.2
264104122016KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.47
267184052016Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis.6
268904222016Variants in the KCNE1 or KCNE3 gene and risk of Ménière's disease: A meta-analysis.3
271620252016Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.8
276260702016Structural basis for KCNE3 modulation of potassium recycling in epithelia.30
279221202016Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.7
264104122016KCNE1 and KCNE3: The yin and yang of voltage-gated K(+) channel regulation.47
267184052016Upregulation of basolateral small conductance potassium channels (KCNQ1/KCNE3) in ulcerative colitis.6
268904222016Variants in the KCNE1 or KCNE3 gene and risk of Ménière's disease: A meta-analysis.3
271620252016Novel exon 1 protein-coding regions N-terminally extend human KCNE3 and KCNE4.8
276260702016Structural basis for KCNE3 modulation of potassium recycling in epithelia.30
279221202016Regulation of human cardiac potassium channels by full-length KCNE3 and KCNE4.7
266683842015KCNE3 acts by promoting voltage sensor activation in KCNQ1.23

Citation

Dessen P

KCNE3 (potassium voltage-gated channel subfamily E regulatory subunit 3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64774/kcne3-(potassium-voltage-gated-channel-subfamily-e-regulatory-subunit-3)