KCNIP2 (potassium voltage-gated channel interacting protein 2)

2014-11-01  

Identity

HGNC
LOCATION
10q24.32
LOCUSID
ALIAS
KCHIP2
FUSION GENES

Other Information

Locus ID:

NCBI: 30819
MIM: 604661
HGNC: 15522
Ensembl: ENSG00000120049

Variants:

dbSNP: 30819
ClinVar: 30819
TCGA: ENSG00000120049
COSMIC: KCNIP2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000120049ENST00000239117Q9NS61
ENSG00000120049ENST00000343195Q9NS61
ENSG00000120049ENST00000348850Q9NS61
ENSG00000120049ENST00000353068Q9NS61
ENSG00000120049ENST00000356640Q9NS61
ENSG00000120049ENST00000358038Q9NS61
ENSG00000120049ENST00000370046A6NFF4
ENSG00000120049ENST00000434163Q9NS61
ENSG00000120049ENST00000461105Q9NS61
ENSG00000120049ENST00000642874A0A2R8Y6D7

Expression (GTEx)

0
50
100
150
200
250

Pathways

PathwaySourceExternal ID
Muscle contractionREACTOMER-HSA-397014
Cardiac conductionREACTOMER-HSA-5576891
Phase 1 - inactivation of fast Na+ channelsREACTOMER-HSA-5576894

References

Pubmed IDYearTitleCitations
306221422019A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca(2+) regulation of Kv4 channels.5
313620182019Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.6
306221422019A polybasic motif in alternatively spliced KChIP2 isoforms prevents Ca(2+) regulation of Kv4 channels.5
313620182019Dynamic palmitoylation regulates trafficking of K channel interacting protein 2 (KChIP2) across multiple subcellular compartments in cardiac myocytes.6
293851762018Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons.4
293851762018Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons.4
282637092017KChIP2 is a core transcriptional regulator of cardiac excitability.19
287354192017Modulation of human Kv4.3/KChIP2 channel inactivation kinetics by cytoplasmic Ca(2).7
282637092017KChIP2 is a core transcriptional regulator of cardiac excitability.19
287354192017Modulation of human Kv4.3/KChIP2 channel inactivation kinetics by cytoplasmic Ca(2).7
273491852016Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling.1
273491852016Potassium Channel Interacting Protein 2 (KChIP2) is not a transcriptional regulator of cardiac electrical remodeling.1
260169052015Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.8
260169052015Two novel Brugada syndrome-associated mutations increase KV4.3 membrane expression and function.8
240960042014A novel KCNQ1 missense mutation identified in a patient with juvenile-onset atrial fibrillation causes constitutively open IKs channels.20

Citation

Dessen P

KCNIP2 (potassium voltage-gated channel interacting protein 2)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64782/kcnip2-(potassium-voltage-gated-channel-interacting-protein-2)