Identity
HGNC
LOCATION
1q42.2
LOCUSID
ALIAS
DPK,HOHO,K2P1,K2p1.1,KCNO1,TWIK-1,TWIK1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 3775
MIM: 601745
HGNC: 6272
Ensembl: ENSG00000135750
Variants:
dbSNP: 3775
ClinVar: 3775
TCGA: ENSG00000135750
COSMIC: KCNK1
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000135750 | ENST00000366621 | O00180 |
| ENSG00000135750 | ENST00000366621 | A0A024R3T2 |
| ENSG00000135750 | ENST00000446915 | Q5T5E6 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38689322 | 2024 | Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer. | 1 |
| 38905316 | 2024 | KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation. | 0 |
| 38689322 | 2024 | Overexpressed KCNK1 regulates potassium channels affecting molecular mechanisms and biological pathways in bladder cancer. | 1 |
| 38905316 | 2024 | KCNK1 promotes proliferation and metastasis of breast cancer cells by activating lactate dehydrogenase A (LDHA) and up-regulating H3K18 lactylation. | 0 |
| 36566598 | 2023 | Identification of KCNK1 as a potential prognostic biomarker and therapeutic target of breast cancer. | 1 |
| 36566598 | 2023 | Identification of KCNK1 as a potential prognostic biomarker and therapeutic target of breast cancer. | 1 |
| 31806709 | 2020 | Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K(+) channel. | 10 |
| 31806709 | 2020 | Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K(+) channel. | 10 |
| 27103460 | 2016 | The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. | 15 |
| 27558721 | 2016 | Exploring the Dynamics of the TWIK-1 Channel. | 6 |
| 27103460 | 2016 | The two-pore domain potassium channel, TWIK-1, has a role in the regulation of heart rate and atrial size. | 15 |
| 27558721 | 2016 | Exploring the Dynamics of the TWIK-1 Channel. | 6 |
| 25001086 | 2014 | A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. | 63 |
| 25001086 | 2014 | A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel. | 63 |
| 21964404 | 2012 | A role for two-pore K⁺ channels in modulating Na⁺ absorption and Cl⁻ secretion in normal human bronchial epithelial cells. | 22 |
Citation
Dessen P
KCNK1 (potassium two pore domain channel subfamily K member 1)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64793/kcnk1-(potassium-two-pore-domain-channel-subfamily-k-member-1)
