Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 56660
MIM: 607366
HGNC: 6274
Ensembl: ENSG00000184261
Variants:
dbSNP: 56660
ClinVar: 56660
TCGA: ENSG00000184261
COSMIC: KCNK12
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000184261 | ENST00000327876 | Q9HB15 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Muscle contraction | REACTOME | R-HSA-397014 |
| Cardiac conduction | REACTOME | R-HSA-5576891 |
| Phase 4 - resting membrane potential | REACTOME | R-HSA-5576886 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37099539 | 2023 | Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors. | 0 |
| 37099539 | 2023 | Regulation of the two-pore domain potassium channel, THIK-1 and THIK-2, by G protein coupled receptors. | 0 |
| 25148687 | 2014 | Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. | 25 |
| 25148687 | 2014 | Tandem pore domain halothane-inhibited K+ channel subunits THIK1 and THIK2 assemble and form active channels. | 25 |
| 24163367 | 2013 | Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. | 14 |
| 24163367 | 2013 | Silencing of the tandem pore domain halothane-inhibited K+ channel 2 (THIK2) relies on combined intracellular retention and low intrinsic activity at the plasma membrane. | 14 |
| 18209473 | 2008 | Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. | 5 |
| 18676988 | 2008 | A high-density association screen of 155 ion transport genes for involvement with common migraine. | 31 |
| 18209473 | 2008 | Cellular localization of THIK-1 (K(2P)13.1) and THIK-2 (K(2P)12.1) K channels in the mammalian kidney. | 5 |
| 18676988 | 2008 | A high-density association screen of 155 ion transport genes for involvement with common migraine. | 31 |
Citation
Dessen P
KCNK12 (potassium two pore domain channel subfamily K member 12)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/64794/kcnk12-(potassium-two-pore-domain-channel-subfamily-k-member-12)
