KCNK16 (potassium two pore domain channel subfamily K member 16)

2014-11-01 Affiliation

Identity

HGNC

KCNK16

LOCATION

6p21.2

LOCUSID

83795

ALIAS

K2p16.1,TALK-1,TALK1

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 83795
MIM: 607369
HGNC: 14464
Ensembl: ENSG00000095981

Variants:

dbSNP: 83795
ClinVar: 83795
TCGA: ENSG00000095981
COSMIC: KCNK16

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000095981	ENST00000373227	Q96T55
ENSG00000095981	ENST00000373229	Q96T55
ENSG00000095981	ENST00000425054	Q96T55
ENSG00000095981	ENST00000437525	Q96T55
ENSG00000095981	ENST00000507712	D6RC57

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Neuronal System	REACTOME	R-HSA-112316
Potassium Channels	REACTOME	R-HSA-1296071
Tandem pore domain potassium channels	REACTOME	R-HSA-1296346
TWIK-related alkaline pH activated K+ channel (TALK)	REACTOME	R-HSA-1299361
Muscle contraction	REACTOME	R-HSA-397014
Cardiac conduction	REACTOME	R-HSA-5576891
Phase 4 - resting membrane potential	REACTOME	R-HSA-5576886

References

Pubmed ID	Year	Title	Citations
28403169	2017	Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.	11
28928238	2017	TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis.	19
28403169	2017	Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells.	11
28928238	2017	TALK-1 channels control β cell endoplasmic reticulum Ca(2+) homeostasis.	19
26239056	2015	Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.	42
26239056	2015	Type 2 Diabetes-Associated K+ Channel TALK-1 Modulates β-Cell Electrical Excitability, Second-Phase Insulin Secretion, and Glucose Homeostasis.	42
12724142	2003	Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.	13
12724142	2003	Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK-1.	13

Citation

Dessen P

KCNK16 (potassium two pore domain channel subfamily K member 16)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64797/kcnk16-(potassium-two-pore-domain-channel-subfamily-k-member-16)