KCTD1 (potassium channel tetramerization domain containing 1)

2014-11-01  

Identity

HGNC
LOCATION
18q11.2
LOCUSID
ALIAS
C18orf5
FUSION GENES

Other Information

Locus ID:

NCBI: 284252
MIM: 613420
HGNC: 18249
Ensembl: ENSG00000134504

Variants:

dbSNP: 284252
ClinVar: 284252
TCGA: ENSG00000134504
COSMIC: KCTD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000134504ENST00000317932Q719H9
ENSG00000134504ENST00000317932A0A024RC45
ENSG00000134504ENST00000408011Q719H9
ENSG00000134504ENST00000408011A0A024RC45
ENSG00000134504ENST00000417602Q719H9
ENSG00000134504ENST00000417602A0A024RC45
ENSG00000134504ENST00000578973J3QLL6
ENSG00000134504ENST00000579973Q719H9
ENSG00000134504ENST00000579973A0A024RC45
ENSG00000134504ENST00000580059A0A2U3U043
ENSG00000134504ENST00000580191J3QRK1
ENSG00000134504ENST00000580638J3KSG1

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
Generic Transcription PathwayREACTOMER-HSA-212436
Transcriptional regulation by the AP-2 (TFAP2) family of transcription factorsREACTOMER-HSA-8864260
Negative regulation of activity of TFAP2 (AP-2) family transcription factorsREACTOMER-HSA-8866904

References

Pubmed IDYearTitleCitations
381131152023KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.3
381131152023KCTD1/KCTD15 complexes control ectodermal and neural crest cell functions, and their impairment causes aplasia cutis.3
334401552021Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron.10
334401552021Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron.10
325531202020AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.16
330002252020KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling.11
325531202020AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis.16
330002252020KCTD1 mutants in scalp‑ear‑nipple syndrome and AP‑2α P59A in Char syndrome reciprocally abrogate their interactions, but can regulate Wnt/β‑catenin signaling.11
313248362019Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants.16
313248362019Molecular basis of the scalp-ear-nipple syndrome unraveled by the characterization of disease-causing KCTD1 mutants.16
263343692016Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.33
275967232016Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity.6
263343692016Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.33
275967232016Bivalent Copper Ions Promote Fibrillar Aggregation of KCTD1 and Induce Cytotoxicity.6
235413442013Mutations in KCTD1 cause scalp-ear-nipple syndrome.39

Citation

Dessen P

KCTD1 (potassium channel tetramerization domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64817/kctd1-(potassium-channel-tetramerization-domain-containing-1)