KIF5C (kinesin family member 5C)

2014-11-01  

Identity

HGNC
LOCATION
2q23.1
LOCUSID
ALIAS
CDCBM2,KINN,NKHC,NKHC-2,NKHC2
FUSION GENES

Other Information

Locus ID:

NCBI: 3800
MIM: 604593
HGNC: 6325
Ensembl: ENSG00000168280

Variants:

dbSNP: 3800
ClinVar: 3800
TCGA: ENSG00000168280
COSMIC: KIF5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168280ENST00000435030O60282
ENSG00000168280ENST00000450621C9JWB9

Expression (GTEx)

0
50
100
150
200
250
300
350

Pathways

PathwaySourceExternal ID
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Dopaminergic synapseKEGGko04728
Dopaminergic synapseKEGGhsa04728
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
373222602024LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression.0
373222602024LncRNA ZNF667-AS1 Targets miR-523-3p/KIF5C Axis to Hinder Colon Cancer Progression.0
349661802022KIF5C deficiency causes abnormal cortical neuronal migration, dendritic branching, and spine morphology in mice.3
361226732022Abnormal course of the corticospinal tracts in KIF5C-related encephalopathy.1
349661802022KIF5C deficiency causes abnormal cortical neuronal migration, dendritic branching, and spine morphology in mice.3
361226732022Abnormal course of the corticospinal tracts in KIF5C-related encephalopathy.1
325112652020Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro.14
325112652020Deletion of the Pseudorabies Virus gE/gI-US9p complex disrupts kinesin KIF1A and KIF5C recruitment during egress, and alters the properties of microtubule-dependent transport in vitro.14
317578892019The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.27
318440332019Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma.6
317578892019The adaptor proteins HAP1a and GRIP1 collaborate to activate the kinesin-1 isoform KIF5C.27
318440332019Reduced miR-203 predicts metastasis and poor survival in esophageal carcinoma.6
302002382018Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis.2
302002382018Kinesin-2 Controls the Motility of RAB5 Endosomes and Their Association with the Spindle in Mitosis.2
290487272017Mutations of KIF5C cause a neurodevelopmental disorder of infantile-onset epilepsy, absent language, and distinctive malformations of cortical development.18

Citation

Dessen P

KIF5C (kinesin family member 5C)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/64928/kif5c-(kinesin-family-member-5c)