ANPEP (alanyl aminopeptidase, membrane)

2003-06-01 Affiliation

Identity

HGNC

ANPEP

LOCATION

15q26.1

LOCUSID

290

ALIAS

APN,CD13,GP150,LAP1,P150,PEPN

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 290
MIM: 151530
HGNC: 500
Ensembl: ENSG00000166825

Variants:

dbSNP: 290
ClinVar: 290
TCGA: ENSG00000166825
COSMIC: ANPEP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000166825	ENST00000300060	P15144
ENSG00000166825	ENST00000300060	A0A024RC61
ENSG00000166825	ENST00000559874	H0YKT6
ENSG00000166825	ENST00000560028	H0YLZ8
ENSG00000166825	ENST00000560030	H0YMC1
ENSG00000166825	ENST00000560137	H0YM04

Expression (GTEx)

100

200

300

400

500

600

700

800

900

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Glutathione metabolism	KEGG	ko00480
Renin-angiotensin system	KEGG	ko04614
Hematopoietic cell lineage	KEGG	ko04640
Glutathione metabolism	KEGG	hsa00480
Renin-angiotensin system	KEGG	hsa04614
Hematopoietic cell lineage	KEGG	hsa04640
Metabolic pathways	KEGG	hsa01100
Metabolism of proteins	REACTOME	R-HSA-392499
Peptide hormone metabolism	REACTOME	R-HSA-2980736
Metabolism of Angiotensinogen to Angiotensins	REACTOME	R-HSA-2022377
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Neutrophil degranulation	REACTOME	R-HSA-6798695

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
15280478	2004	Human coronavirus 229E binds to CD13 in rafts and enters the cell through caveolae.	77
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	62
12634402	2003	Human coronavirus 229E: receptor binding domain and neutralization by soluble receptor at 37 degrees C.	52
17363739	2007	CD13/APN regulates endothelial invasion and filopodia formation.	47
22932899	2012	The X-ray crystal structure of human aminopeptidase N reveals a novel dimer and the basis for peptide processing.	42
17363734	2007	Proteolytic processing of CXCL11 by CD13/aminopeptidase N impairs CXCR3 and CXCR7 binding and signaling and reduces lymphocyte and endothelial cell migration.	41
21879266	2012	Increased CD13 expression reduces reactive oxygen species, promoting survival of liver cancer stem cells via an epithelial-mesenchymal transition-like phenomenon.	41
18495788	2008	CD13 is a novel mediator of monocytic/endothelial cell adhesion.	36
16466852	2006	Aminopeptidase N (APN/CD13) is selectively expressed in vascular endothelial cells and plays multiple roles in angiogenesis.	34
12406907	2003	The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis.	31

Citation

Dessen P

ANPEP (alanyl aminopeptidase, membrane)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/651/anpep-(alanyl-aminopeptidase-membrane)