ANPEP (alanyl aminopeptidase, membrane)

2003-06-01  

Identity

HGNC
LOCATION
15q26.1
LOCUSID
ALIAS
APN,CD13,GP150,LAP1,P150,PEPN
FUSION GENES

Other Information

Locus ID:

NCBI: 290
MIM: 151530
HGNC: 500
Ensembl: ENSG00000166825

Variants:

dbSNP: 290
ClinVar: 290
TCGA: ENSG00000166825
COSMIC: ANPEP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000166825ENST00000300060P15144
ENSG00000166825ENST00000300060A0A024RC61
ENSG00000166825ENST00000559874H0YKT6
ENSG00000166825ENST00000560028H0YLZ8
ENSG00000166825ENST00000560030H0YMC1
ENSG00000166825ENST00000560137H0YM04

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Renin-angiotensin systemKEGGko04614
Hematopoietic cell lineageKEGGko04640
Glutathione metabolismKEGGhsa00480
Renin-angiotensin systemKEGGhsa04614
Hematopoietic cell lineageKEGGhsa04640
Metabolic pathwaysKEGGhsa01100
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Metabolism of Angiotensinogen to AngiotensinsREACTOMER-HSA-2022377
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
378063352024ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and Survival in Esophageal Adenocarcinoma.0
385198892024CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro.0
378063352024ANPEP/CD13 Expression as a Marker of Lymphovascular Invasion and Survival in Esophageal Adenocarcinoma.0
385198892024CD13 expression affects glioma patient survival and influences key functions of human glioblastoma cell lines in vitro.0
367488352023Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer.4
372638842023Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome.0
378171902023CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.2
378921702023Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.0
367488352023Reduced expression of alanyl aminopeptidase is a robust biomarker of non-familial adenomatous polyposis and non-hereditary nonpolyposis colorectal cancer syndrome early-onset colorectal cancer.4
372638842023Altered serum levels of platelet-derived growth factor receptor β and cluster of differentiation 13 suggest a role for pericytes in West syndrome.0
378171902023CD13 facilitates immune cell migration and aggravates acute injury but promotes chronic post-stroke recovery.2
378921702023Aminopeptidase N/CD13 Crosslinking Promotes the Activation and Membrane Expression of Integrin CD11b/CD18.0
351236182022[The Relationship between the Expressions of CD33 and CD13 and the Prognosis of Patients with Multiple Myeloma].0
359386462022Abnormal CD13/HLA-DR Expression Pattern on Myeloblasts Predicts Development of Myeloid Neoplasia in Patients With Clonal Cytopenia of Undetermined Significance.3
362206032022Soluble ANPEP Released From Human Astrocytes as a Positive Regulator of Microglial Activation and Neuroinflammation: Brain Renin-Angiotensin System in Astrocyte-Microglia Crosstalk.7

Citation

Dessen P

ANPEP (alanyl aminopeptidase, membrane)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/651/anpep-(alanyl-aminopeptidase-membrane)