KYNU (kynureninase)

2014-11-01  

Identity

HGNC
KYNU
LOCATION
2q22.2
LOCUSID
8942
ALIAS
KYNUU,VCRL2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8942
MIM: 605197
HGNC: 6469
Ensembl: ENSG00000115919

Variants:

dbSNP: 8942
ClinVar: 8942
TCGA: ENSG00000115919
COSMIC: KYNU

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115919ENST00000264170Q16719
ENSG00000115919ENST00000375773Q16719
ENSG00000115919ENST00000409512Q16719
ENSG00000115919ENST00000410015B8ZZA3
ENSG00000115919ENST00000424385F8WEP1
ENSG00000115919ENST00000612147A0A087WYM2
ENSG00000115919ENST00000613664A0A087WYQ7
ENSG00000115919ENST00000621320A0A087X297

Expression (GTEx)

0
1
2
3
4
5
6
7
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Tryptophan metabolismKEGGko00380
Tryptophan metabolismKEGGhsa00380
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Tryptophan catabolismREACTOMER-HSA-71240
Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolismREACTOMER-HSA-6788656

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
350548252022The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay.0
353622672022Re-sequencing of candidate genes FOXF1, HSPA6, HAAO, and KYNU in 522 individuals with VATER/VACTERL, VACTER/VACTERL-like association, and isolated anorectal malformation.1
350548252022The TZM-bl Reporter Cell Line Expresses Kynureninase That Can Neutralize 2F5-like Antibodies in the HIV-1 Neutralization Assay.0
353622672022Re-sequencing of candidate genes FOXF1, HSPA6, HAAO, and KYNU in 522 individuals with VATER/VACTERL, VACTER/VACTERL-like association, and isolated anorectal malformation.1
340513372021TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway.13
340513372021TDO2 knockdown inhibits colorectal cancer progression via TDO2-KYNU-AhR pathway.13
313329442019A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.14
313329442019A novel role of kynureninase in the growth control of breast cancer cells and its relationships with breast cancer.14
267259962016The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.59
267259962016The tryptophan metabolism enzyme L-kynureninase is a novel inflammatory factor in psoriasis and other inflammatory diseases.59
220129862011A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.7
220129862011A rare variant at the KYNU gene is associated with kynureninase activity and essential hypertension in the Han Chinese population.7
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
208776242010Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.20
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

KYNU (kynureninase)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65151/kynu-(kynureninase)