LAPTM4A (lysosomal protein transmembrane 4 alpha)

2014-11-01  

Identity

HGNC
LAPTM4A
LOCATION
2p24.1
LOCUSID
9741
ALIAS
HUMORF13,LAPTM4,MBNT,Mtrp
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9741
MIM: 618837
HGNC: 6924
Ensembl: ENSG00000068697

Variants:

dbSNP: 9741
ClinVar: 9741
TCGA: ENSG00000068697
COSMIC: LAPTM4A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068697ENST00000175091Q15012
ENSG00000068697ENST00000175091Q6IBP4

Expression (GTEx)

0
100
200
300
400
500
600
700
800
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
LysosomeKEGGko04142
LysosomeKEGGhsa04142

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
385885602024The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus.0
385885602024The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus.0
366750232023New Transcriptomic Biomarkers of 5-Fluorouracil Resistance.3
366750232023New Transcriptomic Biomarkers of 5-Fluorouracil Resistance.3
338363472021LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins.1
338363472021LAPTM4α is targeted from the Golgi to late endosomes/lysosomes in a manner dependent on the E3 ubiquitin ligase Nedd4-1 and ESCRT proteins.1
215532342011LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.7
215532342011LAPTM4A interacts with hOCT2 and regulates its endocytotic recruitment.7

Citation

Dessen P

LAPTM4A (lysosomal protein transmembrane 4 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65172/laptm4a-(lysosomal-protein-transmembrane-4-alpha)