LILRB3 (leukocyte immunoglobulin like receptor B3)

2014-11-01  

Identity

HGNC
LILRB3
LOCATION
19q13.42
LOCUSID
11025
ALIAS
CD85A,HL9,ILT-5,ILT5,LILRA6,LIR-3,LIR3,PIR-B,PIRB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11025
MIM: 604820
HGNC: 6607
Ensembl: ENSG00000204577

Variants:

dbSNP: 11025
ClinVar: 11025
TCGA: ENSG00000204577
COSMIC: LILRB3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000204577ENST00000245620O75022
ENSG00000204577ENST00000346401F8W6G6
ENSG00000204577ENST00000391750O75022
ENSG00000204577ENST00000414379F8WD89
ENSG00000204577ENST00000445347C9JWL8

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
B cell receptor signaling pathwayKEGGko04662
B cell receptor signaling pathwayKEGGhsa04662
Osteoclast differentiationKEGGko04380
Osteoclast differentiationKEGGhsa04380
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellREACTOMER-HSA-198933
Innate Immune SystemREACTOMER-HSA-168249
Neutrophil degranulationREACTOMER-HSA-6798695

References

Pubmed IDYearTitleCitations
364490532023Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.3
365881232023LilrB3 is a putative cell surface receptor of APOE4.7
364490532023Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans.3
365881232023LilrB3 is a putative cell surface receptor of APOE4.7
335268152021Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.3
342718752021KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.7
346868652021Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.14
351220562021LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis.18
335268152021Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population.3
342718752021KLRD1, FOSL2 and LILRB3 as potential biomarkers for plaques progression in acute myocardial infarction and stable coronary artery disease.7
346868652021Epithelial cells remove precancerous cells by cell competition via MHC class I-LILRB3 interaction.14
351220562021LILRB3 supports acute myeloid leukemia development and regulates T-cell antitumor immune responses through the TRAF2-cFLIP-NF-κB signaling axis.18
319152592020The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils.17
328708222020LILRB3 (ILT5) is a myeloid cell checkpoint that elicits profound immunomodulation.24
319152592020The Orphan Immune Receptor LILRB3 Modulates Fc Receptor-Mediated Functions of Neutrophils.17

Citation

Dessen P

LILRB3 (leukocyte immunoglobulin like receptor B3)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/65265/lilrb3-(leukocyte-immunoglobulin-like-receptor-b3)