APCDD1 (APC down-regulated 1)

2003-02-01  

Identity

HGNC
APCDD1
LOCATION
18p11.22
LOCUSID
147495
ALIAS
B7323,DRAPC1,FP7019,HHS,HTS,HYPT1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 147495
MIM: 607479
HGNC: 15718
Ensembl: ENSG00000154856

Variants:

dbSNP: 147495
ClinVar: 147495
TCGA: ENSG00000154856
COSMIC: APCDD1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154856ENST00000355285Q8J025
ENSG00000154856ENST00000423585X6RH63
ENSG00000154856ENST00000578882J3KTQ6
ENSG00000154856ENST00000579685J3QSE3
ENSG00000154856ENST00000582723J3KTR1
ENSG00000154856ENST00000584596V9GY82

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
100
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
203935622010APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex.57
211524112010Systematic identification of placental epigenetic signatures for the noninvasive prenatal detection of Edwards syndrome.11
255929702015The WNT inhibitor APCDD1 sustains the expression of β-catenin during the osteogenic differentiation of human dental follicle cells.8
202009782010Replication of previous genome-wide association studies of bone mineral density in premenopausal American women.7
259466822015Apcdd1 stimulates oligodendrocyte differentiation after white matter injury.7
304964862019Super-enhancer-associated MEIS1 promotes transcriptional dysregulation in Ewing sarcoma in co-operation with EWS-FLI1.5
282427652017A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.3
286981412017Epigenetic silencing of the Wnt antagonist APCDD1 by promoter DNA hyper-methylation contributes to osteosarcoma cell invasion and metastasis.3
225128112012A recurrent mutation in the APCDD1 gene responsible for hereditary hypotrichosis simplex in a large Chinese family.0

Citation

Dessen P

APCDD1 (APC down-regulated 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/667/apcdd1-(apc-down-regulated-1)