Identity
HGNC
LOCATION
14q11.2
LOCUSID
ALIAS
APE,APE1,APEN,APEX,APX,HAP1,REF1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 328
MIM: 107748
HGNC: 587
Ensembl: ENSG00000100823
Variants:
dbSNP: 328
ClinVar: 328
TCGA: ENSG00000100823
COSMIC: APEX1
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA164713176 | Platinum compounds | Chemical | VariantAnnotation | not associated | PD | 28791697 | |
| PA443622 | Carcinoma, Non-Small-Cell Lung | Disease | VariantAnnotation | not associated | PD | 28791697 | |
| PA443937 | Drug Toxicity | Disease | VariantAnnotation | not associated | PD | 28791697 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37806619 | 2024 | Coordination between human DNA polymerase β and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair. | 1 |
| 38056311 | 2024 | In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer. | 2 |
| 38236479 | 2024 | Investigation of APE1 and OGG1 expression in chronic hemodialysis patients. | 0 |
| 38418695 | 2024 | APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. | 2 |
| 38436697 | 2024 | Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer. | 0 |
| 38554110 | 2024 | Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@DNA probe. | 0 |
| 37806619 | 2024 | Coordination between human DNA polymerase β and apurinic/apyrimidinic endonuclease 1 in the course of DNA repair. | 1 |
| 38056311 | 2024 | In vitro and In vivo evidence demonstrating chronic absence of Ref-1 Cysteine 65 impacts Ref-1 folding configuration, redox signaling, proliferation and metastasis in pancreatic cancer. | 2 |
| 38236479 | 2024 | Investigation of APE1 and OGG1 expression in chronic hemodialysis patients. | 0 |
| 38418695 | 2024 | APE1 inhibition enhances ferroptotic cell death and contributes to hepatocellular carcinoma therapy. | 2 |
| 38436697 | 2024 | Apurinic/apyrimidinic endodeoxyribonuclease 1 (APE1) promotes stress granule formation via YBX1 phosphorylation in ovarian cancer. | 0 |
| 38554110 | 2024 | Live-cell imaging of human apurinic/apyrimidinic endonuclease 1 in the nucleus and nucleolus using a chaperone@DNA probe. | 0 |
| 35750470 | 2023 | Activation of NOTCH signaling via DLL1 is mediated by APE1-redox-dependent NF-κB activation in oesophageal adenocarcinoma. | 8 |
| 36689867 | 2023 | Fluorescently labeled human apurinic/apyrimidinic endonuclease APE1 reveals effects of DNA polymerase β on the APE1-DNA interaction. | 2 |
| 36855946 | 2023 | AUF1 Recognizes 8-Oxo-Guanosine Embedded in DNA and Stimulates APE1 Endoribonuclease Activity. | 1 |
Citation
Dessen P
APEX1 (apurinic/apyrimidinic endodeoxyribonuclease 1)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/669/apex1-(apurinic-apyrimidinic-endodeoxyribonuclease-1)
