Identity
HGNC
LOCATION
6p21.2
LOCUSID
ALIAS
FIGLER2,KIAA1246,SALM1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 57497
MIM: 612808
HGNC: 21226
Ensembl: ENSG00000156564
Variants:
dbSNP: 57497
ClinVar: 57497
TCGA: ENSG00000156564
COSMIC: LRFN2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000156564 | ENST00000338305 | Q9ULH4 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Neuronal System | REACTOME | R-HSA-112316 |
| SALM protein interactions at the synapses | REACTOME | R-HSA-8849932 |
| Protein-protein interactions at synapses | REACTOME | R-HSA-6794362 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37802603 | 2023 | Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8(+) T cell infiltration and functional transition. | 4 |
| 37802603 | 2023 | Bladder cancer intrinsic LRFN2 drives anticancer immunotherapy resistance by attenuating CD8(+) T cell infiltration and functional transition. | 4 |
| 35879265 | 2022 | LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/β-Catenin and NF-κB signaling pathway. | 4 |
| 35879265 | 2022 | LRFN2 binding to NMDAR inhibits the progress of ESCC via regulating the Wnt/β-Catenin and NF-κB signaling pathway. | 4 |
| 31605628 | 2020 | Genetic variants of DNAH11 and LRFN2 genes and their association with ovarian and breast cancer. | 10 |
| 32880595 | 2020 | LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir. | 1 |
| 31605628 | 2020 | Genetic variants of DNAH11 and LRFN2 genes and their association with ovarian and breast cancer. | 10 |
| 32880595 | 2020 | LRFN2 gene variant rs2494938 provides susceptibility to esophageal cancer in the population of Jammu and Kashmir. | 1 |
| 31053115 | 2019 | Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma. | 4 |
| 31053115 | 2019 | Intronic polymorphisms in genes LRFN2 (rs2494938) and DNAH11 (rs2285947) are prognostic indicators of esophageal squamous cell carcinoma. | 4 |
| 26486473 | 2016 | Heterozygous deletion of the LRFN2 gene is associated with working memory deficits. | 14 |
| 26486473 | 2016 | Heterozygous deletion of the LRFN2 gene is associated with working memory deficits. | 14 |
| 22174418 | 2012 | Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons. | 6 |
| 22174418 | 2012 | Dileucine and PDZ-binding motifs mediate synaptic adhesion-like molecule 1 (SALM1) trafficking in hippocampal neurons. | 6 |
| 20379614 | 2010 | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. | 78 |
Citation
Dessen P
LRFN2 (leucine rich repeat and fibronectin type III domain containing 2)
Atlas Genet Cytogenet Oncol Haematol. 2014-11-01
Online version: http://atlasgeneticsoncology.org/gene/68577/lrfn2-(leucine-rich-repeat-and-fibronectin-type-iii-domain-containing-2)
