Identity
HGNC
LOCATION
Xp11.3
LOCUSID
ALIAS
A-RAF,ARAF1,PKS2,RAFA1
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 369
MIM: 311010
HGNC: 646
Ensembl: ENSG00000078061
Variants:
dbSNP: 369
ClinVar: 369
TCGA: ENSG00000078061
COSMIC: ARAF
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000078061 | ENST00000290277 | Q96II5 |
| ENSG00000078061 | ENST00000377039 | P10398 |
| ENSG00000078061 | ENST00000377045 | P10398 |
| ENSG00000078061 | ENST00000377045 | A0A024R178 |
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA29444 | HRAS | Gene | Pathway | associated | |||
| PA30196 | KRAS | Gene | Pathway | associated | |||
| PA30584 | MAP2K1 | Gene | Pathway | associated | |||
| PA30587 | MAP2K2 | Gene | Pathway | associated | |||
| PA30932 | MRAS | Gene | Pathway | associated | |||
| PA31768 | NRAS | Gene | Pathway | associated | |||
| PA34861 | RRAS | Gene | Pathway | associated | |||
| PA7000 | sorafenib | Chemical | MultilinkAnnotation | associated | 24569458 |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 37572153 | 2023 | Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling. | 1 |
| 37572153 | 2023 | Somatic ARAF mutations in pediatric Langerhans cell histiocytosis: clinicopathologic, genetic and functional profiling. | 1 |
| 35302851 | 2022 | ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers. | 4 |
| 35613620 | 2022 | ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. | 6 |
| 35302851 | 2022 | ARAF suppresses ERBB3 expression and metastasis in a subset of lung cancers. | 4 |
| 35613620 | 2022 | ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1. | 6 |
| 33953400 | 2021 | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. | 46 |
| 33953400 | 2021 | ARAF mutations confer resistance to the RAF inhibitor belvarafenib in melanoma. | 46 |
| 32814086 | 2020 | Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. | 38 |
| 32814086 | 2020 | Linc01232 promotes the metastasis of pancreatic cancer by suppressing the ubiquitin-mediated degradation of HNRNPA2B1 and activating the A-Raf-induced MAPK/ERK signaling pathway. | 38 |
| 26891695 | 2016 | Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. | 11 |
| 26891695 | 2016 | Differential localization of A-Raf regulates MST2-mediated apoptosis during epithelial differentiation. | 11 |
| 25608663 | 2015 | Massive parallel sequencing uncovers actionable FGFR2-PPHLN1 fusion and ARAF mutations in intrahepatic cholangiocarcinoma. | 122 |
| 25674762 | 2015 | Aberrant expression of COT is related to recurrence of papillary thyroid cancer. | 0 |
| 26508523 | 2015 | A-Raf: A new star of the family of raf kinases. | 15 |
Citation
Dessen P
ARAF (A-Raf proto-oncogene, serine/threonine kinase)
Atlas Genet Cytogenet Oncol Haematol. 2003-02-01
Online version: http://atlasgeneticsoncology.org/gene/686
