LRRC4C (leucine rich repeat containing 4C)

2014-11-01  

Identity

HGNC
LRRC4C
LOCATION
11p12
LOCUSID
57689
ALIAS
NGL-1,NGL1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 57689
MIM: 608817
HGNC: 29317
Ensembl: ENSG00000148948

Variants:

dbSNP: 57689
ClinVar: 57689
TCGA: ENSG00000148948
COSMIC: LRRC4C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000148948ENST00000278198Q9HCJ2
ENSG00000148948ENST00000527150Q9HCJ2
ENSG00000148948ENST00000528697Q9HCJ2
ENSG00000148948ENST00000530763Q9HCJ2
ENSG00000148948ENST00000533474E9PLP4
ENSG00000148948ENST00000619527Q9HCJ2

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Cell adhesion molecules (CAMs)KEGGko04514
Axon guidanceKEGGhsa04360
Cell adhesion molecules (CAMs)KEGGhsa04514

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
277599172017Implication of LRRC4C and DPP6 in neurodevelopmental disorders.25
277599172017Implication of LRRC4C and DPP6 in neurodevelopmental disorders.25
239864732013Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.22
239864732013Trans-induced cis interaction in the tripartite NGL-1, netrin-G1 and LAR adhesion complex promotes development of excitatory synapses.22
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
200294092010Association of polymorphisms in the SLIT2 axonal guidance gene with anger in suicide attempters.2
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
145954432003The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.83
145954432003The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.83
145954432003The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.83
145954432003The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons.83

Citation

Dessen P

LRRC4C (leucine rich repeat containing 4C)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68635/lrrc4c-(leucine-rich-repeat-containing-4c)